{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:03:06Z","timestamp":1790251386980,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess long\u2010term hearing outcomes in patients treated with third\u2010generation bisphosphonates for otosclerosis\u2010related progressive sensorineural hearing loss (SNHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series review<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case series review of patients with otosclerosis and progressive SNHL. Patients were treated with either risedronate or zoledronate after a diagnosis of otosclerosis with a significant SNHL component. Bone conduction pure tone threshold averages (BC\u2010PTAs) and word recognition scores (WRS) before and after bisphosphonate administration in long\u2010term follow\u2010up was analyzed. Significant change in BC\u2010PTA was defined as greater than 10dB or between 4% and 18% in WRS based on binomial variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients were identified and 14 ears met inclusion criteria. Three patients were female and the mean age was 48.3\u2009\u00b1\u200910.3 years. The mean duration between treatment with bisphosphonate administration and long\u2010term post\u2010treatment follow\u2010up audiometry was 87.6\u2009\u00b1\u200918.3 months, with a range of 61.6 to 109.1 months and median of 89.2 months. Analysis using BC\u2010PTA and WRS demonstrated that 11 ears remained stable while 2 improved and 1 worsened. No patient experienced any major complication as the result of bisphosphonate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with third\u2010generation bisphosphonates is associated with stability in otosclerosis\u2010related sensorineural hearing over 5\u2010 to 9\u2010year period. These results suggest that such medications may prevent the progression of SNHL in patients with otosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 (Case series).<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.91","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T10:27:05Z","timestamp":1505989625000},"page":"262-268","source":"Crossref","is-referenced-by-count":13,"title":["Third\u2010generation bisphosphonates for cochlear otosclerosis stabilizes sensorineural hearing loss in long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-7769","authenticated-orcid":false,"given":"Taha A.","family":"Jan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology , Massachusetts Eye and Ear Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron 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