{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:02:46Z","timestamp":1777921366596,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of antibiotics in ear surgery is still controversial. The aim of this study was to assess their need in cholesteatoma surgery when performing obliteration with S53P4 bioactive glass, a biocompatible material with antibacterial properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted in a tertiary referral center between January 2017 and May 2019. Sixty\u2010nine consecutive patients, who underwent surgery for cholesteatoma removal and\/or rehabilitation of canal\u2010wall\u2010down mastoidectomy with mastoid and epitympanic obliteration using S53P4 granules were included. Before 2019, antibiotics were routinely used (group \u201cw\/AB\u201d). Patients received intravenous antibiotics during surgery, oral treatment was continued for 7\u2009days and topical antibiotics for 1\u00a0month. After 2019, no antibiotics were administered (group \u201cw\/oAB\u201d). The primary outcome was the occurrence of early surgical site infection. Secondary outcomes were late infection, anatomic and functional results at 3 and 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three patients were included in group \u201cw\/oAB\u201d and 46 in group \u201cw\/AB\u201d, with no significant differences in demographics, medical history or follow\u2010up. Five ears (22%) in group \u201cw\/oAB\u201d developed an early infection compared with 2 (4%) in group \u201cw\/AB\u201d (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). The relative risk was 6.11, 95CI%[1.09;31.96]. Infections were successfully treated with antibiotics, and no patient underwent surgical removal of the granules. No late infections or complications were observed. There was no difference in graft failure or air\u2010bone gap closure at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peri\u2010\/post\u2010operative antibiotics prevent early infection in obliteration surgery with S53P4 granules. Infections can be treated medically without complications or require removal of the implanted material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.923","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T10:53:37Z","timestamp":1663152817000},"page":"1584-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibiotics in mastoid and epitympanic obliteration with<scp>S53P4<\/scp>bioactive glass: A retrospective study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-1511","authenticated-orcid":false,"given":"Lauranne","family":"Alciato","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, AP\u2010HP H\u00f4pitaux Universitaires Piti\u00e9\u2010Salp\u00eatri\u00e8re Charles\u2010Foix, Service d'Oto\u2010Rhino\u2010Laryngologie Paris 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