{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:32:13Z","timestamp":1747150333548,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chorda tympani nerve (CTN) function may be damaged more by two\u2010stage than by one\u2010stage surgery for middle ear cholesteatoma. However, few studies have reported the relationship between two\u2010stage cholesteatoma surgery and CTN function. This study aimed to investigate CTN function after two\u2010stage surgery for cholesteatoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, 35 patients underwent two\u2010stage canal wall up tympanoplasty (CWUT). Perioperative CTN function was assessed using questionnaires and electrogustometry (EGM). Participants were categorized into minor, major, and section groups, based on the degree of CTN manipulation during surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first\u2010stage surgery, posterior tympanotomy with an intact canal wall reduced the degree of CTN manipulation. The incidence of taste disorder after the first\u2010stage surgery was 71.4%. Postoperative taste disorder and the EGM threshold improved early in the minor manipulation group. In the second\u2010stage surgery, no new CTN damage occurred, even if this surgery involved removal of residual cholesteatoma. The incidence of taste disorder after second\u2010stage surgery was less than that after first\u2010stage surgery, independent of CTN preservation. However, the recovery rate of the EGM threshold after second\u2010stage surgery was significantly lower in the section group than in those with CTN preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CTN function, including symptoms and EGM threshold, can be preserved during two\u2010stage cholesteatoma surgery if care is taken to preserve the CTN in both the first\u2010 and second\u2010stage surgeries. A two\u2010stage CWUT, ensuring an intact bony annulus, may be effective to facilitate CTN preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.939","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T10:35:40Z","timestamp":1666002940000},"page":"2035-2042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Change in chorda tympani nerve function after two\u2010stage tympanoplasty for cholesteatoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-7425","authenticated-orcid":false,"given":"Riu","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Hyogo Medical University  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Miuchi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Hyogo Medical University  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Ikehata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Amagasaki Chuo Hospital  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Hyogo Medical University  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Hyogo Medical University  Hyogo 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disorder after middle ear surgery","volume":"5","author":"Sakagami M","year":"2009","journal-title":"J Int Adv Otol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_22_1","DOI":"10.1017\/S0022215110000733"}],"container-title":["Laryngoscope Investigative 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