{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:03:58Z","timestamp":1789218238618,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objective<\/jats:title><jats:p>To compare functional hearing and tinnitus outcomes in treated large (~\u20093\u2009cm) vestibular schwannoma (VS) and posterior fossa meningioma cohorts, and construct willingness\u2010to\u2010accept profiles for an experimental brain implant to treat unilateral hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010way MANOVA model with two independent variables (tumor type; time from treatment) and three dependent variables (hearing effort of tumor ear; abbreviated Speech, Spatial, and Qualities of Hearing scale (SSQ12); Tinnitus Functional Index (TFI)) was used to analyze data from VS (<jats:italic>N<\/jats:italic>\u00a0=\u00a032) and meningioma (<jats:italic>N<\/jats:italic>\u00a0=\u00a050) patients who were treated at a tertiary care center between 2010 and 2020. A query to probe acceptance of experimental treatment for hearing loss relative to expected benefit was used to construct willingness\u2010to\u2010accept profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumor type was statistically significant on the combined dependent variables analysis (<jats:italic>F<\/jats:italic>[3, 76]\u00a0=\u00a019.172, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0005, Wilks' \u039b\u00a0=\u00a00.569). Meningioma showed better outcome for hearing effort (<jats:italic>F<\/jats:italic>[1, 76]\u00a0=\u00a014.632, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0005) and SSQ12 (<jats:italic>F<\/jats:italic>[1, 76]\u00a0=\u00a016.164, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0005), but not for TFI (<jats:italic>F<\/jats:italic>[1, 76]\u00a0=\u00a01.247, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.268) on univariate two\u2010way ANOVA analyses. Superior hearing effort and SSQ12 indices in the short\u2010term (&lt;\u20092\u2009years) persisted in the long\u2010term (&gt;\u20092\u2009years) (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.017). At the 60% speech understanding level, 77% of respondents would accept an experimental brain implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hearing outcome is better for posterior fossa meningioma compared to VS. Most patients with hearing loss in the tumor ear would consider a brain implant if the benefit level would be comparable to a cochlear implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.957","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T10:58:55Z","timestamp":1666868335000},"page":"2057-2063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treated large posterior fossa vestibular schwannoma and meningioma: Hearing outcome and <scp>willingness\u2010to\u2010accept<\/scp> brain implant for unilateral deafness"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-5065","authenticated-orcid":false,"given":"Nicole T.","family":"Jiam","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin A.","family":"Morshed","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek S.","family":"Bhutada","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan D.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve W.","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Henderson Sabes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip V.","family":"Theodosopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1724-4944","authenticated-orcid":false,"given":"Steven W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  San Francisco California USA"},{"name":"Surgical Services, San Francisco Veterans Affairs Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.02.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_335_17"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4980562"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"129","article-title":"Cerebellopontine angle meningiomas. 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