{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:52:14Z","timestamp":1789577534382,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["57522433"],"award-info":[{"award-number":["57522433"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Laryngoscope Investig Oto"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The paraglottic space is an essential anatomic compartment of the larynx. It is central to the spread of laryngeal cancer and to the choice of conservative laryngeal surgery and many phonosurgical procedures. Since its description, 60\u2009years ago, the surgical anatomy of the paraglottic space was sparsely revisited. Amid the era of endoscopic and transoral microscopic functional surgery of the larynx, we provide here a long\u2010awaited description of the inside\u2010out anatomy of the paraglottic space.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Using an endoscope equipped with a 3D camera, we dissected 10 hemilarynges from 5 fresh frozen cadavers from the inside out. Before dissection, we labeled the vessels through injecting them with colored latex. We explored the paraglottic space emphasizing its shape, boundaries, and contents. We documented our findings through endoscopic photography and video recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The paraglottic space is a spacious tetrahedral space located parallel not only to the glottic, but also to the subglottic and the supraglottic compartments of the laryngeal lumen. It has musculo\u2010cartilaginous, musculo\u2010fibrous, and mucosal boundaries. It is separated from the pyriform sinus only by mucosa. A cushion of fat surrounds its vascular and to a lesser extent its neural contents. Harbored intrinsic laryngeal muscles are endoscopically identifiable within the space, namely the thyroarytenoid, the lateral, and posterior cricoarytenoid muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The endoscopic description of the paraglottic space partly fills the knowledge gap on the laryngeal anatomy from the inside out. It opens the door for novel diagnostic methods and for ultraconservative functional laryngeal interventions under endoscopic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A<\/jats:p><\/jats:sec>","DOI":"10.1002\/lio2.979","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T06:46:42Z","timestamp":1671173202000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The inside\u2010out surgical anatomy of the paraglottic space a video\u2010guided endoscopic dissection"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-1351","authenticated-orcid":false,"given":"Hazem Mohamed Aly","family":"Saleh","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit, National Institute of Laser Enhanced Sciences Cairo University Giza Egypt"},{"name":"Klinik f\u00fcr Audiologie und Phoniatrie Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Seidel","sequence":"additional","affiliation":[{"name":"Berliner Simulations &amp; Trainingszentrum (BeST), Department of Anatomy, Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"J\u00f6ns","sequence":"additional","affiliation":[{"name":"Berliner Simulations &amp; Trainingszentrum (BeST), Department of Anatomy, Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"M\u00fcrbe","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Audiologie und Phoniatrie Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeus","family":"Nawka","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Audiologie und Phoniatrie Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"308","article-title":"A histological demonstration of the development of laryngeal connective tissue compartments","volume":"66","author":"Tucker GF","year":"1962","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196306000-00010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00879272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-32-2-287"},{"key":"e_1_2_7_6_1","first-page":"432","article-title":"Supraglottic anatomy the pre\u2010 or the peri\u2010epiglottic space?","volume":"3","author":"Maguire A","year":"1974","journal-title":"Can J Otolaryngol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310201204"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26878"},{"key":"e_1_2_7_9_1","first-page":"503","article-title":"Intralaryngeal barriers to the spread of cancer","volume":"103","author":"Kirchner JA","year":"1987","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050031"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.3.304"},{"key":"e_1_2_7_12_1","first-page":"35","article-title":"Supraglottal horizontal laryngectomy in the treatment of supraglottal cancers of the laryngeal border. 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