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However, interpretation is complicated since <jats:italic>ad libitum<\/jats:italic> feeding of such diets induces hyperphagia and upregulates expression of liver fatty acid binding protein (L\u2010FABP)\u2014a protein intimately involved in fatty acid and glucose regulation of lipid metabolism. Wild\u2010type (WT) and <jats:italic>L\u2010fabp<\/jats:italic> gene ablated (LKO) mice were pair\u2010fed either high\u2010fat diet (HFD) or high\u2010fat\/high\u2010glucose diet (HFGD) wherein total carbohydrate was maintained constant but the proportion of glucose was increased at the expense of fructose. In LKO mice, the pair\u2010fed HFD increased body weight and lean tissue mass (LTM) but had no effect on fat tissue mass (FTM) or hepatic fatty vacuolation as compared to pair\u2010fed WT counterparts. These LKO mice exhibited upregulation of hepatic proteins in fatty acid uptake and cytosolic transport (caveolin and sterol carrier protein\u20102), but lower hepatic fatty acid oxidation (decreased serum \u03b2\u2010hydroxybutyrate). LKO mice pair\u2010fed HFGD also exhibited increased body weight; however, these mice had increased FTM, not LTM, and increased hepatic fatty vacuolation as compared to pair\u2010fed WT counterparts. These LKO mice also exhibited upregulation of hepatic proteins in fatty acid uptake and cytosolic transport (caveolin and acyl\u2010CoA binding protein, but not sterol carrier protein\u20102), but there was no change in hepatic fatty acid oxidation (serum \u03b2\u2010hydroxybutyrate) as compared to pair\u2010fed WT counterparts.<\/jats:p>","DOI":"10.1002\/lipd.12238","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T03:00:16Z","timestamp":1587438016000},"page":"309-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High\u2010Fat <scp>Pair\u2010Fed<\/scp> Mice"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-4612","authenticated-orcid":false,"given":"Gregory 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