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In this study, we investigated the effects of human\u2010derived low\u2010density lipoproteins (LDL), high\u2010density lipoproteins (HDL), and HDL\u2010associated proteins apolipoprotein A1 (apoA1) and serum amyloid A (SAA) on markers of viability, cholesterol flux, and differentiation in K562 cells\u2014a bone marrow\u2010derived, stem\u2010like erythroleukemia cell model of chronic myelogenous leukemia (CML). We further evaluated whether lipoprotein\u2010mediated effects were altered by concomitant LXR activation. We observed that LDL promoted higher K562 cell viability in a dose\u2010 and time\u2010dependent manner and increased cellular cholesterol concentrations, while LXR activation by the agonist TO901317 ablated these effects. LXR activation in the presence of HDL, apoA1 and SAA\u2010rich HDL suppressed K562 cell viability, while robustly inducing mRNA expression of ATP\u2010binding cassette transporter A1 (<jats:italic>ABCA1<\/jats:italic>). HDL and its associated proteins additionally suppressed mRNA expression of anti\u2010apoptotic B\u2010cell lymphoma\u2010extra large (<jats:italic>BCL\u2010xL)<\/jats:italic>, and the erythroid lineage marker 5\u2032\u2010aminolevulinate synthase 2 (<jats:italic>ALAS2<\/jats:italic>), while SAA\u2010rich HDL induced mRNA expression of the megakaryocytic lineage marker integrin subunit alpha 2b (<jats:italic>ITGA2B<\/jats:italic>). Together, these findings suggest that lipoproteins and LXR may impact the viability and characteristics of CML cells.<\/jats:p>","DOI":"10.1002\/lipd.12254","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T11:39:40Z","timestamp":1592566780000},"page":"615-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low\u2010Density Lipoproteins, High\u2010Density Lipoproteins (HDL), and HDL\u2010Associated Proteins Differentially Modulate Chronic Myelogenous Leukemia Cell Viability"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-5030","authenticated-orcid":false,"given":"Catherine J.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Biology Fairfield University  Fairfield CT 06824 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