{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:47:04Z","timestamp":1761007624343,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005645","name":"B\u1ed9 Gi\u00e1o d\u1ee5c v\u00e0 \u00d0\u00e0o t\u1ea1o","doi-asserted-by":"publisher","award":["B2014\u201017\u201047"],"award-info":[{"award-number":["B2014\u201017\u201047"]}],"id":[{"id":"10.13039\/501100005645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apolipoprotein A\u2010V encoded by apolipoprotein 5 (<jats:italic>APOA5<\/jats:italic>) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the <jats:italic>APOA5<\/jats:italic>\u2010rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity\u2010related traits (body mass index, waist circumference, hip circumference, and waist\u2010to\u2010hip ratio) on this association. A case\u2013control study was conducted with a total of 154 dyslipidemia cases and 389 controls at the age of 6 to 10 recruited at 31 primary schools in Hanoi city of Vietnam. Genotype for <jats:italic>APOA5<\/jats:italic>\u2010rs662799 polymorphism was determined by the restriction fragment length polymorphism analysis. The association of <jats:italic>APOA5<\/jats:italic>\u2010rs662799 polymorphism with dyslipidemia adjusting for age, sex, residence, and obesity\u2010related traits was analyzed by binary logistic regression analysis. The results showed that in comparison with T\/T and T\/C carriers, the C\/C carriers had a higher concentration of serum TAG in cases (<jats:italic>p<\/jats:italic>\u2009=0.049). Carriers of the C allele (C\/C\u2009+\u2009T\/C) had higher risk for developing dyslipidemia and hypertriglyceridemia than subjects with T\/T genotype (odds ratio, OR = 1.7, <jats:italic>p<\/jats:italic>\u2009=0.0062 and OR = 1.6, <jats:italic>p<\/jats:italic> = 0.026, respectively). The association remained significant after adjusting for age, gender, residence, and obesity status (OR = 1.75, <jats:italic>p<\/jats:italic> = 0.006 and OR = 1.53, <jats:italic>p<\/jats:italic> = 0.049, respectively) or other obesity\u2010related traits. The study suggested that the <jats:italic>APOA5<\/jats:italic>\u2010rs662799 polymorphism may be a determinant of dyslipidemia and hypertriglyceridemia in Vietnamese children, independent of obesity\u2010related traits.<\/jats:p>","DOI":"10.1002\/lipd.12270","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T19:08:42Z","timestamp":1597086522000},"page":"683-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The <scp><i>APOA5<\/i><\/scp>\u2010rs662799 Polymorphism Is a Determinant of Dyslipidemia in Vietnamese Primary School Children"],"prefix":"10.1002","volume":"55","author":[{"given":"Nguyen T. 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