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Men have higher plasma TAG and impaired TAG clearance compared to women, which may contribute to sex differences in risk of cardiovascular disease. Understanding mechanisms of sex differences in TAG metabolism may yield novel therapeutic targets to prevent cardiovascular disease. Cholesteryl ester transfer protein (CETP) is a lipid shuttling protein known for its effects on high\u2010density lipoprotein (HDL) cholesterol levels. Although mice lack CETP, we previously demonstrated that transgenic CETP expression in female mice alters TAG metabolism. The impact of CETP on TAG metabolism in males, however, is not well understood. Here, we demonstrate that CETP expression increases plasma TAG in males, especially in very\u2010low density lipoprotein (VLDL), by impairing postprandial plasma TAG clearance compared to wild\u2010type (WT) males. Gonadal hormones were required for CETP to impair TAG clearance, suggesting a role for sex hormones for this effect. Testosterone replacement in the setting of gonadectomy was sufficient to restore the effect of CETP on TAG. Lastly, liver androgen receptor (AR) was required for CETP to increase plasma TAG. Thus, expression of CETP in males raises plasma TAG by impairing TAG clearance <jats:italic>via<\/jats:italic> testosterone signaling to AR. Further understanding of how CETP and androgen signaling impair TAG clearance may lead to novel approaches to reduce TAG and mitigate risk of cardiovascular disease.<\/jats:p>","DOI":"10.1002\/lipd.12271","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:11:16Z","timestamp":1597191076000},"page":"17-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cholesteryl Ester Transfer Protein Impairs Triglyceride Clearance <i>via<\/i> Androgen Receptor in Male Mice"],"prefix":"10.1002","volume":"56","author":[{"given":"Brian T.","family":"Palmisano","sequence":"first","affiliation":[{"name":"Tennessee Valley Health System, Veterans Affairs  Nashville TN USA"},{"name":"Department of Molecular Physiology &amp; Biophysics Vanderbilt University School of Medicine  Nashville TN USA"},{"name":"Division of Cardiovascular Medicine Stanford University Medical Center  Stanford CA 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