{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:09:36Z","timestamp":1791317376830,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fatty acid composition of human follicular fluid is important for oocyte development and for pregnancy following <jats:italic>in vitro<\/jats:italic> fertilization (IVF). This study investigated whether a dietary intervention that included an increase in marine omega\u20103 fatty acids, olive oil and vitamin D alters the fatty acid composition of human follicular fluid. The association of lifestyle factors with follicular fluid fatty acid composition was also investigated. Fifty\u2010five couples awaiting IVF were randomized to receive the 6\u2010week treatment intervention of olive oil for cooking, an olive oil\u2010based spread, and a daily supplement drink enriched with vitamin D and the marine omega\u20103 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and 56 couples were randomized to receive placebo equivalents. Dietary questionnaires were completed, and samples of blood were taken before and after the intervention. Follicular fluid was collected at oocyte retrieval and the fatty acid profile assessed using gas chromatography. In the control group, individual fatty acids in red blood cells and follicular fluid were significantly correlated. Furthermore, a healthier diet was associated with a lower percentage of follicular fluid arachidonic acid. The follicular fluid of women in the treatment group contained significantly higher amounts of EPA and DHA compared to the control group, while the omega\u20106 fatty acids linoleic, \u03b3\u2010linolenic, dihomo\u2010\u03b3\u2010linolenic, and arachidonic were lower. This is the first report of a dietary intervention altering the fatty acid composition of follicular fluid in humans. Further research is required to determine whether this intervention improves oocyte quality.<\/jats:p>","DOI":"10.1002\/lipd.12288","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T22:35:02Z","timestamp":1602542102000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6\u2010Week Dietary Intervention That Includes Marine Omega\u20103 Fatty Acids"],"prefix":"10.1002","volume":"56","author":[{"given":"Alexandra J.","family":"Kermack","sequence":"first","affiliation":[{"name":"NIHR Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton  Southampton UK"},{"name":"Centre for Human Development, Stem Cells &amp; Regeneration, Faculty of Medicine University of Southampton  Southampton UK"},{"name":"Complete Fertility Centre, Department of Obstetrics &amp; 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