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Although it is well known that FA stimulate CCK secretion, whether 2\u2010MAG have the CCK\u2010releasing activity remains unclear. We examined the CCK\u2010releasing activity of four commercially available 2\u2010MAG in a murine CCK\u2010producing cell line, STC\u20101, and the molecular mechanism underlying 2\u2010MAG\u2010induced CCK secretion. CCK released from the cells was measured using ELISA. Among four 2\u2010MAG (2\u2010palmitoyl, 2\u2010oleoyl, 2\u2010linoleoyl, and 2\u2010arachidonoyl monoacylglycerols) examined, 2\u2010arachidonoyl glycerol (2\u2010AG) potently stimulated CCK secretion in a dose\u2010dependent manner. Structurally related compounds, such as 2\u2010arachidonoyl glycerol ether and 1\u2010arachidonoyl glycerol, did not stimulate CCK secretion. Both arachidonic acid and 2\u2010AG stimulated CCK secretion at 100\u2009\u03bcM, but only 2\u2010AG did at 50\u2009\u03bcM. 2\u2010AG\u2010induced CCK secretion but not arachidonic acid\u2010induced CCK secretion was attenuated by treatment with a cannabinoid receptor 1 (CB1) antagonist. These results indicate that a specific 2\u2010MAG, 2\u2010AG, directly stimulates CCK secretion via CB1.<\/jats:p>","DOI":"10.1002\/lipd.12323","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T07:45:47Z","timestamp":1631864747000},"page":"603-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["2\u2010Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine <scp>STC<\/scp>\u20101 cells via cannabinoid receptor <scp>CB1<\/scp>"],"prefix":"10.1002","volume":"56","author":[{"given":"Keita","family":"Ochiai","sequence":"first","affiliation":[{"name":"Graduate School of Agriculture Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hirooka","sequence":"additional","affiliation":[{"name":"J\u2010Oil Mills, Inc.  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