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Several studies have focused on its biological effects, but the metabolism once consumed is not clear yet. The aim of this work was to evaluate the effects of two different daily doses of JO on serum parameters and fatty acid (FA) profile of mice tissues after 4\u2009weeks of feeding. No significant changes on body weight gain, food intake, or tissue weight were determined after 0.7 or 2\u00a0ml\/kg of JO supplementation compared to control animals. Significantly lower blood low\u2010density lipoproteins\u2010cholesterol (20\u00a0mg\/dl) and glucose (~147\u2013148\u00a0mg\/dl) levels were detected in both oil\u2010treated groups compared to control (31.2 and 165\u00a0mg\/dl, respectively). Moreover, jacaric acid was partially converted into <jats:italic>cis<\/jats:italic>9, <jats:italic>trans<\/jats:italic>11 conjugated linoleic acid (CLA) and thus further incorporated into tissues. Liver evidenced the highest total conjugated fatty acid content (1.1%\u20132.2%), followed by epididymal (0.7%\u20131.9%) and mesenteric (1.4%\u20131.8%) fat. Lower saturated and higher unsaturated fatty acid content was detected in both oil\u2010treated groups compared to control. Our results support the safety of JO and its potential application with a functional or nutraceutical propose, by increasing human CLNA consumption and further availability of CLA.<\/jats:p>","DOI":"10.1002\/lipd.12327","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T01:29:49Z","timestamp":1636162189000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues"],"prefix":"10.1002","volume":"57","author":[{"given":"Carina P.","family":"Van Nieuwenhove","sequence":"first","affiliation":[{"name":"Laboratorio de Ecofisiolog\u00eda Tecnol\u00f3gica Centro de Referencia para Lactobacilos (CERELA\u2010CONICET)  San Miguel de Tucum\u00e1n Argentina"},{"name":"Facultad de Ciencias Naturales e IML Universidad Nacional de Tucum\u00e1n  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"del Huerto Moyano","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Ecoetol\u00f3gicas de Moscas de la Fruta y sus Enemigos Naturales (LIEMEN) Planta Piloto de Procesos Industriales Microbiol\u00f3gicos (PROIMI\u2010CONICET)  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido A.","family":"Van Nieuwenhove","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Ecoetol\u00f3gicas de Moscas de la Fruta y sus Enemigos Naturales (LIEMEN) Planta Piloto de Procesos Industriales Microbiol\u00f3gicos (PROIMI\u2010CONICET)  San Miguel de Tucum\u00e1n Argentina"},{"name":"Fundaci\u00f3n Miguel Lillo  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecofisiolog\u00eda Tecnol\u00f3gica Centro de Referencia para Lactobacilos (CERELA\u2010CONICET)  San Miguel de Tucum\u00e1n Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Luna Pizarro","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Miguel Lillo  San Miguel de Tucum\u00e1n Argentina"},{"name":"Facultad de Ingenier\u00eda Universidad Nacional de Jujuy  San Salvador de Jujuy Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2020.100218"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"Alarc\u00f3n G Roco J Medina A Van Nieuwenhove C Medina M Jerez\u00a0S. 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