{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T21:01:47Z","timestamp":1763499707462,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dyslipidemia is the main risk factor for coronary artery disease and is characterized by alterations in concentrations of lipids, including low\u2010density lipoprotein cholesterol (LDL\u2010c), high\u2010density lipoprotein cholesterol (HDL\u2010c), and triacylglycerols. The participation of several genes in the development of dyslipidemia has been evidenced. Genetic variants in <jats:italic>SLC22A1<\/jats:italic> have been associated with elevated cholesterol and LDL\u2010c levels. The aim of this study was to evaluate the association between single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>SLC22A1<\/jats:italic> gene with atherogenic risk lipid levels in Mexican women. Anthropometric and biochemical measurements were performed, and four SNPs in <jats:italic>SLC22A1<\/jats:italic> were genotyped by real\u2010time polymerase chain reaction. The Hardy\u2013Weinberg equilibrium was verified, and haplotype frequencies were calculated. We found significant differences between the allele frequencies of the SNPs analyzed with those reported in Mexico and in the world, which could be due to differences in the historical admixture of the women studied. Generalized linear models were evaluated to determine the association between genotypes and haplotypes with lipids levels. We identified a significant increase in total cholesterol and LDL\u2010c levels in women who were carriers of the GA and AG genotypes of the polymorphisms rs628031 and rs594709, respectively, significant effect that is also shown in a dominant inheritance model. Interestingly, we identified an important relationship of the AGC\u2010GAT haplotype with the elevation in LDL\u2010c levels and AGA\u2010GAT haplotype with the elevation in HDL\u2010c levels. On the other hand, we found a strong linkage disequilibrium between the polymorphisms studied. Our results show that variants in the <jats:italic>SLC22A1<\/jats:italic> gene influence serum levels of atherogenic risk lipids, suggesting that these variants probably affect the function of organic cation transporter\u20101 and therefore, on the regulation of lipid metabolism.<\/jats:p>","DOI":"10.1002\/lipd.12334","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:53:04Z","timestamp":1639961584000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic variants in <i>SLC22A1<\/i> are related to serum lipid levels in Mexican women"],"prefix":"10.1002","volume":"57","author":[{"given":"Jos\u00e9 \u00c1ngel","family":"Cahua\u2010Pablo","sequence":"first","affiliation":[{"name":"Laboratorio en Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime H\u00e9ctor","family":"G\u00f3mez\u2010Zamudio","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica Hospital de Especialidades \u201cBernardo Sep\u00falveda\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Res\u00e9ndiz\u2010Abarca","sequence":"additional","affiliation":[{"name":"Laboratorio en Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vianet Argelia","family":"Tello\u2010Flores","sequence":"additional","affiliation":[{"name":"Laboratorio en Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesica","family":"Eulogio\u2010Metodio","sequence":"additional","affiliation":[{"name":"Laboratorio en Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"Ram\u00edrez\u2010Vargas","sequence":"additional","affiliation":[{"name":"Laboratorio en Epidemiolog\u00eda Cl\u00ednica y Molecular, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica Hospital de Especialidades \u201cBernardo Sep\u00falveda\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"del Carmen Alarc\u00f3n\u2010Romero","sequence":"additional","affiliation":[{"name":"Laboratorio en Citopatolog\u00eda e Histoqu\u00edmica Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas, Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Matia\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio en Obesidad y Diabetes, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Anah\u00ed","family":"Marino\u2010Ortega","sequence":"additional","affiliation":[{"name":"Laboratorio en Obesidad y Diabetes, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. 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