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However, their association with cardiometabolic multimorbidity (CMM) is less known. We evaluated a wide range of lipid profiles and lipid ratios, including low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C), very\u2010low\u2010density lipoprotein\u2010cholesterol (VLDL\u2010C), high\u2010density lipoprotein\u2010cholesterol (HDL\u2010C), and apoA1 and B, as well triglyceride and total cholesterol with risk of incident CMM. In 1728 men aged 52.5\u2009\u00b1\u20095.2\u2009years from the Kuopio Ischaemic Heart Disease were included in this study. We defined CMM as coexisting of two or more of stroke, type 2 diabetes mellitus (T2D), coronary heart disease (CHD). A Cox proportional hazard regression method was applied to evaluate the risk of CMM against the exposures. During the mean follow\u2010up of 22.4\u2009years, 335 men suffered from CMM conditions. Higher serum triglyceride and VLDL concentrations were associated with a higher risk of coexisting T2D\u2010CHD (HRs 1.99 (95% CI, 1.12\u20133.53) and HRs 1.79 (95% CI, 1.04\u20133.11), respectively. Whereas higher HDL was associated with lower incident [HRs 0.49 (95% CI, 0.40\u20131.00)]. The HRs for coexisting T2D\u2010CHD was 2.02 (95% CI, 1.01\u20133.07) for total cholesterol\/HDL\u2010C, 1.85 (95% CI, 1.04\u20133.29) for triglyceride\/HDL\u2010C, 1.69 (95% CI, 1.01\u20132.31) for Non\u2010HDL\u2010C\/HDL\u2010C, and 1.89 (95% CI, 1.03\u20132.46) for apoB\/apoA1. In contrast, serum LDL\u2010C\/apoB ratios were inversely associated with the risk of coexisting T2D\u2010CHD [HRs 0.50 (95% CI, 0.28\u20130.90)]. No associations were observed between our exposures and other CMM conditions. In conclusion, elevated triglyceride, VLDL\u2010C, total cholesterol\/HDL\u2010C, TG\/HDL\u2010C, apoB\/apoA1 as well as lower LDL\u2010C\/apoB were independently associated with the higher risk of T2D\u2010CHD coexistence.<\/jats:p>","DOI":"10.1002\/lipd.12337","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T06:29:38Z","timestamp":1642660178000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men: The Kuopio Ischaemic Heart Disease Risk Factor Study"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-3909","authenticated-orcid":false,"given":"Behnam","family":"Tajik","sequence":"first","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Voutilainen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Kauhanen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshen","family":"Mazidi","sequence":"additional","affiliation":[{"name":"Medical Research Council Population Health Research Unit University of Oxford  Oxford UK"},{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford  Oxford UK"},{"name":"Department of Twin Research and Genetic Epidemiology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. 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