{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:41:39Z","timestamp":1760964099694,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"4-5","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860597"],"award-info":[{"award-number":["81860597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0907302"],"award-info":[{"award-number":["2017YFC0907302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study investigated the correlation of plasma A\u2010FABP with glucose dysregulation under different body mass index (BMI) and metabolic states in a Han Chinese population from Yunnan plateau. We cross\u2010sectionally analyzed data from the China Multi Ethnic Cohort, Yunnan province. Participants were divided into two groups. Group A contained 297 obese individuals with metabolic syndrome (MetS). Group B contained 326 age\u2010, sex\u2010, and region\u2010matched normal BMI subjects without MetS. Glucose dysregulation was defined as elevated fasting plasma glucose (FPG) (FPG \u2265 5.6\u2009mmol\/L or current use of oral hypoglycemic agents or insulin). Circulating A\u2010FABP were assayed by ELISA method. Binary and multiple regression analyses were preformed to evaluate the correlation between A\u2010FABP and glucose dysregulation. Plasma A\u2010FABP level was significantly higher in group A compared with group B (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Plasma A\u2010FABP level correlated positively with elevated FPG in group A (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.120, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.039), but negatively with elevated FPG in group B (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.115, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.039). Multiple logistic regression analysis revealed that A\u2010FABP was an independent predictor for elevated FPG in group A (<jats:italic>\u03b2<\/jats:italic>, 0.028; 95% CI, 1.001\u20131.056; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but not in group B (<jats:italic>\u03b2<\/jats:italic>, \u22120.008; 95% CI, 0.882\u20131.117; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In this study, A\u2010FABP was an independent risk factor for glucose dysregulation in obese individuals with MetS living in the Yunnan plateau, but not for those without obesity and MetS.<\/jats:p>","DOI":"10.1002\/lipd.12353","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:08:47Z","timestamp":1656727727000},"page":"257-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between adipocyte fatty acid binding protein and glucose dysregulation is closely associated with obesity and metabolic syndrome: A cohort of Han Chinese population from Yunnan plateau"],"prefix":"10.1002","volume":"57","author":[{"given":"Juan","family":"Huang","sequence":"first","affiliation":[{"name":"School of Public Health Kunming Medical University  Kunming 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