{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:49:37Z","timestamp":1779346177367,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU102\u2010ASIA\u201004\u201008"],"award-info":[{"award-number":["CMU102\u2010ASIA\u201004\u201008"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of lipopolysaccharides (LPS), which can be caused by poor diets and sedentary lifestyles that contribute to liver inflammation. There is promising research on a new class of lipids called fatty acid esters of hydroxy fatty acids (FAHFAs), which have been shown to potentiate insulin release and exert an anti\u2010inflammatory effect. Specifically, one type of FAHFA called 9\u2010POHSA (palmitoleic acid ester of 9\u2010hydroxy stearic acid) has been studied for its potential to attenuate inflammation\u2010related indexes induced by LPS in hepatocytes, which play a critical role in the progression of liver inflammation. This study found that following LPS treatment, tumor necrosis factor\u2010 \u03b1, interleukin\u20106, and connective tissue growth factor (CTGF) were upregulated and increased cell migration, but 9\u2010POHSA pre\u2010treatment attenuated the upregulation of these markers and prevented cell migration induced by LPS. Using flowcytometry analysis, intracellular reactive oxygen species (ROS) was found to be responsible for CTGF upregulation. In addition, the effects of 9\u2010POHSA were likely associated with its inhibition of the activation of the NF\u2010kB. These results suggest that 9\u2010POHSA has potential as a therapy for liver inflammation and fibrosis by attenuating inflammation\u2010related indexes induced by LPS in hepatocytes. This study provides important insight into the mechanisms of liver inflammation and the potential for new treatments to address liver diseases.<\/jats:p>","DOI":"10.1002\/lipd.12380","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:35:32Z","timestamp":1692668132000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>9\u2010POHSA<\/scp> prevents <scp>NF\u2010kB<\/scp> activation and ameliorates <scp>LPS<\/scp>\u2010induced inflammation in rat hepatocytes"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-6814","authenticated-orcid":false,"given":"Jiro Hasegawa","family":"Situmorang","sequence":"first","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Buddhist Tzu Chi General Hospital Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Center for Biomedical Research National Research and Innovation Agency (BRIN)  Cibinong Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colorectal Surgery Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Wen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn\u2010Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Bioinnovation Center Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Department of Neurosurgery, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation  Hualien 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