{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:26:16Z","timestamp":1777141576322,"version":"3.51.4"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG\u201024706"],"award-info":[{"award-number":["IG\u201024706"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["940045"],"award-info":[{"award-number":["940045"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega\u20106 and omega\u20103 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case\u2013control study of Iran (IROPICAN study). We used multivariate logistic regression models to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between PUFAs intake and CRC risk. Our results showed that gamma\u2010linolenic acid (18:3 n\u20106, GLA), arachidonic acid (20:4n\u20106, ARA), a\u2010linolenic acid (Cis\u201018:3n\u20103, ALA), eicosapentaenoic acid (20:5n\u20103, EPA), docosahexaenoic acid (22:6n\u20103, DHA) consumption was not associated with the risk of CRC. However, the OR of linoleic acid (18: 2n\u20106, LA) intake was 1.47 (95% CI 1.01\u20132.14, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) for proximal colon and that of docosapentaenoic acid (22:5n\u20103, DPA) intake was 1.33 (95% CI 1.05\u20131.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) for rectum. This study indicates a high level of LA is associated with an increased risk of proximal colon cancer, and DPA intake was positively associated with rectum cancer risk. Furthermore, our study noted a high intake of n\u20106 (from vegetable oils) compared to n\u20103 PUFAs (from fish and seafood) in this population. Public awareness and government support is needed to increase fish and seafood production and consumption in Iran.<\/jats:p>","DOI":"10.1002\/lipd.12386","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T01:16:36Z","timestamp":1706577396000},"page":"41-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of dietary intake of specific polyunsaturated fatty acids (<scp>PUFAs<\/scp>) on colorectal cancer risk in Iran"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-9128","authenticated-orcid":false,"given":"Monireh Sadat","family":"Seyyedsalehi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Cancer Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hadji","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Health Sciences Unit, Faculty of Social Sciences Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Collatuzzo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Rashidian","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Sasanfar","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Chajes","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Stony Brook Cancer Center Stony Brook University  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazem","family":"Zendehdel","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Cancer Biology Research Center Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665114000585"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.06.031"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00445-1"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310912"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000027498.94238.a3"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-004-1259-6"},{"key":"e_1_2_14_8_1","first-page":"225","article-title":"Polyunsaturated fatty acids (n\u20103 PUFAs) and inflammatory bowel disease (IBD): pathogenesis and treatment","volume":"8","author":"Belluzzi A","year":"2004","journal-title":"European Review for Medical & Pharmacological Ences"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114114"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61649-9"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200403000-00006"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2016.1115097"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo01404c"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00162-2"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122645"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510002096"},{"key":"e_1_2_14_17_1","first-page":"2751","article-title":"\u03c9\u20103 and \u03c9\u20106 polyunsaturated fatty acids","volume":"12","author":"D'Angelo S","year":"2020","journal-title":"Obesity Cancer Nutr"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0750"},{"key":"e_1_2_14_19_1","volume-title":"Legacy release, nutrient data laboratory, Beltsville human nutrition research center","year":"2019"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071738"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5020015"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-330-1_35"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1059870"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005393"},{"key":"e_1_2_14_25_1","first-page":"1","article-title":"Food composition tables for the Near East","volume":"26","year":"1982","journal-title":"FAO Food Nutr Pap"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107670"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8879227"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1526S"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2276326"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2021.27"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1810-9_61"},{"key":"e_1_2_14_32_1","unstructured":"Diet Nutrition Physical Activity and Cancer: A Global Perspective on behalf of AICR WCRF and WKOF.2018Available from:https:\/\/www.wcrf.org\/diet-activity-and-cancer\/cancer-types\/colorectal-cancer\/"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmhimx.2016.11.001"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.804101"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860902718747"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199804)33:4<409::AID-AJIM12>3.0.CO;2-2"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0891"},{"key":"e_1_2_14_38_1","volume-title":"StatPearls","author":"Lotfollahzadeh S","year":"2022"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.850059"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8848161"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.07.034"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-003-1074-0"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2011.00302.x"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58895-7"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-018-1039-7"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.04.013"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33289"},{"key":"e_1_2_14_48_1","unstructured":"MusaigerAO.Food composition tables for Kingdom of Bahrain.2011."},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33196"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.5.1321"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/539426"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23729"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx314"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endinu.2020.01.004"},{"key":"e_1_2_14_55_1","first-page":"594","article-title":"Cancer in Iran 2008 to 2025: recent incidence trends and short\u2010term predictions of the future burden","volume":"149","author":"Roshandel G","year":"2021","journal-title":"Cancer Epidemiol"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.10.020"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-015-0254-4"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25802"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.12.004"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.07.010"},{"key":"e_1_2_14_61_1","article-title":"Meat intake and risk of colorectal cancer: a large case\u2010control study in Iran","author":"Seyyedsalehi MS","journal-title":"JHPN"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1017720"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224912"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(02)00253-6"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<670::AID-IJC10>3.0.CO;2-A"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28878"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516000349"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.3.532"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23980"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1fo10133a"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2022.102441"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02777-9"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.06.013"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/31243"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2011.01.002"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.131378"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:16:04Z","timestamp":1760962564000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1002\/lipd.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/lipd.12386"],"URL":"https:\/\/doi.org\/10.1002\/lipd.12386","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"assertion":[{"value":"2023-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}