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We performed a case\u2013control study to examine the association between ALS diagnosis and serum levels of bile acids. Sporadic and familial ALS patients, age\u2010 and sex\u2010matched healthy controls, and presymptomatic gene carriers who donated blood samples were included. Non\u2010fasted serum samples stored at \u221280\u00b0C were used for the analysis. Serum bile acid levels were measured by liquid chromatography\u2010mass spectrometry (LC\u2013MS). Concentrations of 15 bile acids were obtained, 5 non\u2010conjugated and 10 conjugated, and compared between ALS versus control groups (presymptomatic gene carriers + healthy controls) using the Wilcoxon\u2010Rank\u2010Sum test. In total, 80 participants were included: 31 ALS (17 sporadic and 14 familial ALS); 49 controls (22 gene carriers, 27 healthy controls). The mean age was 50\u2009years old and 50% were male. In the ALS group, 45% had familial disease with a pathogenic variant in <jats:italic>C9orf72<\/jats:italic> (29%), <jats:italic>TARDBP<\/jats:italic> (10%), <jats:italic>FUS<\/jats:italic> (3%), and <jats:italic>CHCHD10<\/jats:italic> (3%) genes. In the control group, 43% carried pathogenic variants: <jats:italic>C9orf72<\/jats:italic> (27%), <jats:italic>SOD1<\/jats:italic> (10%), and <jats:italic>FUS<\/jats:italic> (6%). The serum levels of UDCA, TUDCA, and GUDCA trended higher in the ALS group compared to controls (median 27 vs. 7\u2009nM, 4 vs. 3\u2009nM, 110 vs. 47\u2009nM, <jats:italic>p<\/jats:italic>\u2010values 0.04, 0.06, 0.04, respectively). No significant group differences were found in other bile acids serum levels. In conclusion, the serum level of UDCA, TUDCA, GUDCA trended higher in ALS patients compared to controls, and no evidence of deficiencies was found.<\/jats:p>","DOI":"10.1002\/lipd.12390","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:45:05Z","timestamp":1707277505000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alteration of serum bile acids in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"59","author":[{"given":"Ikjae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Biomarkers Core Laboratory, Irving Institute for Clinical and Translational Research Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Cell Biology and Naomi Berrie Diabetes Center Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129401"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01165-15"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.08.034"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12664"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00335"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2583"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.22.2647"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121471"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.217"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600275R"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2020.1828475"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.04.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27091"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916945"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.10.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010047"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.05.007"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8731-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00042-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174341"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.12390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:03:31Z","timestamp":1760969011000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1002\/lipd.12390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/lipd.12390"],"URL":"https:\/\/doi.org\/10.1002\/lipd.12390","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}