{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:04Z","timestamp":1761006424225,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aimed to assess the effect of high\u2010intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetic men. A prospective study, conducted between March 2021 and July 2022, including 60 men with type 2 diabetes, aged 40\u201365\u2009years, statin\u2010free, and in whom treatment with high\u2010intensity statin was indicated. The patients had two visits, before and 6\u2009months after a daily intake of 40\u2009mg of atorvastatin. During each visit, they underwent a clinical examination, and a fasting blood sample was collected for biological and hormonal measurements. There was a significant increase in the prevalence of decreased libido (from 22% to 47%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and a significant decrease in the frequency of sexual intercourse (from 4 [1\u20138] to 3 [0\u20134] per month, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). The median ADAM's score significantly increased (from 4 [2\u20137] to 6 [3\u20138], <jats:italic>p<\/jats:italic>\u2009=\u20090.000). Twenty\u2010two percent of the patients developed gynecomastia. The median total, bioavailable and free testosterone significantly decreased from 15.1 (11.4\u201317.4), 6.3 (5.0\u20137.8), and 0.27 (0.22\u20130.33) nmol\/L to 12.7 (10.7\u201315.9), 5.7 (4.4\u20137.0), and 0.24 (0.19\u20130.30) nmol\/L, respectively, with no change in FSH and LH levels. Three patients (5%) developed hypogonadism (testosterone &lt;8\u2009nmol\/L). There was a significant decrease in DHEAS from 4.5 (2.8\u20136.1) to 3.8\u2009\u03bcmol\/L (2.6\u20135.6) and no change in cortisol and vitamin D levels. High\u2010intensity statin therapy decreased androgen levels in type 2 diabetic men with significant clinical impact.<\/jats:p>","DOI":"10.1002\/lipd.12399","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T03:09:37Z","timestamp":1716174577000},"page":"135-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of high\u2010intensity statin therapy on steroid hormones and vitamin D in type 2 diabetic men: A prospective self\u2010controlled study"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-9885","authenticated-orcid":false,"given":"Melika","family":"Chihaoui","sequence":"first","affiliation":[{"name":"Department of Endocrinology, La Rabta University Hospital, Faculty of Medicine of Tunis University Tunis El Manar  Tunis 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