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In this study, we investigated the effects of UVB irradiation on cholesterol metabolism in the liver. Hairless mice were exposed to UVB (1.6\u2009J\/cm<jats:sup>2<\/jats:sup>) irradiation. Dorsal skin and liver samples were collected 24\u2009h after exposure. Total RNA was extracted from the skin and liver tissues, and used for DNA microarray analysis and real\u2010time polymerase chain reaction (PCR). Hepatic mRNA expression of <jats:italic>Cyp7a1<\/jats:italic> revealed a 4.4\u2010fold decrease in the UVB (+) group compared to that in the UVB (\u2212) group. No differences were observed in the expression of the other genes related to cholesterol metabolism. Additionally, the level of hepatic total cholesterol in the UVB (+) group was significantly higher than in the UVB (\u2212) group. These findings suggest that acute UVB irradiation increases total cholesterol levels and decreases Cyp7a1 expression in the liver.<\/jats:p>","DOI":"10.1002\/lipd.12407","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T07:48:53Z","timestamp":1719992933000},"page":"181-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute ultraviolet B irradiation increases cholesterol and decreases Cyp7a1 expression in the liver of female mice"],"prefix":"10.1002","volume":"59","author":[{"given":"Takumi","family":"Yamane","sequence":"first","affiliation":[{"name":"Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience Tokyo University of Agriculture  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okumoto","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Safety, Faculty of 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