{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:34:17Z","timestamp":1761006857827,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To examine the associations of apolipoprotein E (APOE) carrier status and lipid profiles with sleep disorders, including excessive daytime sleepiness (EDS) and probable rapid eye movement sleep behavior disorder (pRBD), among patients with early Parkinson's disease (PD) over 5\u2010year follow\u2010up periods. The Parkinson's Progression Markers Initiative is a multicenter cohort study based on an ongoing and open\u2010ended registry. Data from baseline and 5\u2010year follow\u2010up visits from participants of de novo PD were analyzed. Longitudinal associations of APOE carrier status and lipid profiles with sleep disorders were estimated via linear mixed\u2010effects models. A total of 657 participants with complete APOE genotypes were enrolled at baseline. Among them, 153 (25.3%) had available lipid profiles at baseline. In the linear mixed\u2010effects models, baseline APOE \u03b52\/\u03b53\/\u03b54 carrier status did not exhibit significant associations with EDS and pRBD (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) in all models. However, reduced high\u2010density lipoprotein (HDL) and elevated triglycerides (TG) were associated with developing EDS (\u03b2\u2009=\u2009\u22120.04, 95% CI: \u22120.07, \u22120.00) and pRBD (\u03b2\u2009=\u20090.01, 95% CI: 0.00, 0.02) in PD patients, respectively. In the APOE \u03b54+ subgroup, decreased HDL and increased TG displayed substantial associations with developing EDS and sleep disorders (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in all models, respectively, whereas no significant differences were noted in the APOE \u03b54\u2212 subgroup (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Our study did not demonstrate a clear association between APOE \u03b52\/\u03b53\/\u03b54 and sleep disorders in PD patients. However, the presence of APOE \u03b54 was associated with changes in lipid profiles, notably affecting TG and HDL levels.<\/jats:p>","DOI":"10.1002\/lipd.12428","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T23:40:06Z","timestamp":1734651606000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal associations of lipid profiles with sleep disorders in patients with Parkinson's disease"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-2868","authenticated-orcid":false,"given":"Meijie","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health (Shenzhen) Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health (Shenzhen) Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health (Shenzhen) Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-9725","authenticated-orcid":false,"given":"Yiqiang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health (Shenzhen) Sun Yat\u2010Sen University  Shenzhen China"},{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm 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