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While the digestion of long\u2010 and medium\u2010chain TG is well established, the process for SCTG remains unclear. This study investigated SCTG digestion by administering 2\u2009mmol of triacetin to rats and analyzing acetin, acetic acid, and glycerol levels in the portal blood and small intestine. Triacetin was fully degraded in the upper gastrointestinal tract and absorbed as acetic acid and glycerol. Glycerol influx into the liver promoted gluconeogenesis, while acetate activated AMPK, resulting in the suppression of fatty acid synthesis\u2010related genes and the upregulation of fatty acid \u03b2\u2010oxidation\u2010related genes. These findings demonstrate that triacetin not only serves as a substrate for energy metabolism but also regulates hepatic gene expression, highlighting its dual role as both a metabolic substrate and signaling molecule. Triacetin thus shows potential as a dietary modulator for improving metabolic health.<\/jats:p>","DOI":"10.1002\/lipd.12433","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T01:04:42Z","timestamp":1738371882000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Digestion and absorption of triacetin, a short\u2010chain triacylglycerol"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-3261","authenticated-orcid":false,"given":"Yukihiro","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Nutrition Kobe Gakuin University  Kobe City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Nutrition Kobe Gakuin University  Kobe City 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