{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:05:04Z","timestamp":1776153904416,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have suggested that low\u2010dose statin monotherapy may be insufficient for target LDL\u2010C levels. In this randomized, double\u2010blind, multicenter phase 3 trial, we evaluated the efficacy of combined ezetimibe and low\u2010dose atorvastatin in 222 Korean patients with primary hypercholesterolemia. Participants received either 10\u2010mg ezetimibe\/5\u2010mg atorvastatin (EZE10\/ATV5), 10\u2010mg ezetimibe (EZE10), 5\u2010mg atorvastatin (ATV5), or 10\u2010mg atorvastatin (ATV10). At 8\u2009weeks, EZE10\/ATV5 achieved the greatest LDL\u2010C reduction (\u221244.8%) compared with EZE10 (\u221212.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), ATV5 (\u221227.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and ATV10 (\u221232.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0012). The combination therapy showed the highest LDL\u2010C goal achievement rate (41.1% vs. EZE10 8.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; ATV5 10.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; ATV10 27.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0342), particularly in moderate to high\u2010risk patients. Additionally, EZE10\/ATV5 had the lowest adverse events among all groups (6.9% vs. 15.0%, 12.3%, and 27.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.017), with most events being mild. These findings suggest that the combination of ezetimibe and low\u2010dose atorvastatin provides superior lipid\u2010lowering efficacy with an improved safety profile, offering an effective treatment for primary hypercholesterolemia in Korean patients.<\/jats:p>","DOI":"10.1002\/lipd.12442","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T23:23:11Z","timestamp":1745018591000},"page":"317-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of low\u2010dose atorvastatin plus ezetimibe for primary hypercholesterolemia: A randomized, double\u2010blind, multicenter phase 3 trial"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-9302","authenticated-orcid":false,"given":"Tae Oh","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyounghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gil Medical Center Gachon University of Medicine and Science  Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck\u2010Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dongsan Hospital Keimyung University College of Medicine  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine  Busan 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Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Seon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Yeungnam University Hospital  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok\u2010Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital  Yongin Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyung\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ulsan University Hospital, University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ewha Womans University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Uk","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ilsan Paik Hospital, Inje University, College of Medicine  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae\u2010Hyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Inha University Hospital  Incheon Republic of 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