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Several genes essential for iron acquisition, transport, and regulation have been studied. Previous studies have shown that growth in an iron\u2010limited medium alters the lipid compositions of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    cells. In the present study, we performed a mass spectrometry\u2010based lipid analysis of two major iron acquisition pathway proteins: an iron transporter, Ftr1 (ferrous permease), and a closely linked copper transporter, Ccc2. Deletions of\n                    <jats:italic>FTR1<\/jats:italic>\n                    or\n                    <jats:italic>CCC2<\/jats:italic>\n                    lead to significant changes in the lipid profile of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , especially the phospholipid and sphingolipid metabolism. For example, both \u0394\n                    <jats:italic>ftr1<\/jats:italic>\n                    and \u0394\n                    <jats:italic>ccc2<\/jats:italic>\n                    mutants showed depleted sphingolipid and steryl ester contents, but not much change in their DAG and TAG contents. The phospholipid profile of \u0394\n                    <jats:italic>ccc2<\/jats:italic>\n                    cells was quite unique with a much elevated PG content. The overall phospholipid profile of \u0394\n                    <jats:italic>ftr1<\/jats:italic>\n                    was not much different from the wild type. Both \u0394\n                    <jats:italic>ftr1<\/jats:italic>\n                    and \u0394\n                    <jats:italic>ccc2<\/jats:italic>\n                    cells showed significant differences in their molecular lipid species compositions. These lipid perturbations correlated with the susceptible response towards the drugs targeting lipid biogenesis and iron acquisition in \u0394\n                    <jats:italic>ftr1<\/jats:italic>\n                    and \u0394\n                    <jats:italic>ccc2<\/jats:italic>\n                    mutants. Taken together, this study shows that iron pathway proteins such as Ftr1 and Ccc2 are closely linked to lipid metabolism and iron acquisition in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Understanding the mechanism of this lipid\u2010iron association should be useful in exploring the two pathways for understanding the mechanism of iron uptake and designing the combinatorial drug therapies.\n                  <\/jats:p>","DOI":"10.1002\/lipd.12455","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T01:34:41Z","timestamp":1751333681000},"page":"443-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mass Spectrometry\u2010Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in\n                    <scp>\n                      <i>Candida albicans<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"60","author":[{"given":"Sana Akhtar","family":"Usmani","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushboo","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basharat","family":"Ali","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology Amity University Gurgaon  Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumya","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyanshi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Zoology and Environmental Science Gurukula Kangri (Deemed to Be University)  Haridwar Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra","family":"Prasad","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology Amity University Gurgaon  Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-6696","authenticated-orcid":false,"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow Uttar Pradesh 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