{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:48:44Z","timestamp":1789523324397,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIC MH002903"],"award-info":[{"award-number":["ZIC MH002903"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Omega\u20103 and omega\u20106 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega\u20103 and reducing omega\u20106 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced headache pain in humans. However, the extent to which blood levels reflect trigeminovascular tissues remains unclear. We sought to determine whether oxylipin precursor PUFA levels in blood reflect those in the meninges, cranial arteries, and trigeminal ganglia. Precursor PUFA compositions of post\u2010mortem blood and trigeminovascular tissue specimens from 70 individuals, procured from the Human Brain Collection Core at the National Institute of Mental Health, were quantified. Regression models adjusted for confounders examined relationships between blood and tissue PUFA levels. Eicosapentaenoic acid in blood was associated with levels in cranial arteries, meninges, and trigeminal ganglia [\n                    <jats:italic>logged coefficients<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    value): 0.29 (0.019); 0.37 (&lt;\u20090.001); 0.25 (0.009)]. Other PUFAs, including linoleic acid, arachidonic acid, n\u20106 docosapentaenoic acid, and docosahexaenoic acid, also showed significant associations between blood and meninges and\/or trigeminal ganglia levels. These findings support using blood measurements of certain PUFAs as a proxy for their concentration in tissues directly involved in headache pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70010","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:00:31Z","timestamp":1758510031000},"page":"55-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues"],"prefix":"10.1002","volume":"61","author":[{"given":"Daisy","family":"Zamora","sequence":"first","affiliation":[{"name":"Lipid Peroxidation Unit, Laboratory of Clinical Investigation National Institute on Aging  Baltimore Maryland USA"},{"name":"Department of Physical Medicine and Rehabilitation University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-8586","authenticated-orcid":false,"given":"Mark S.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Lipid Peroxidation Unit, Laboratory of Clinical Investigation National Institute on Aging  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon F.","family":"Majchrzak\u2010Hong","sequence":"additional","affiliation":[{"name":"Intramural Program of the National Institute on Alcohol Abuse and Alcoholism NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Ness","family":"Shipley","sequence":"additional","affiliation":[{"name":"Intramural Program of the National Institute on Alcohol Abuse and Alcoholism NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Salem","sequence":"additional","affiliation":[{"name":"Intramural Program of the National Institute on Alcohol Abuse and Alcoholism NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann I.","family":"Scher","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Sapio","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine, Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Iadarola","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine, Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Ramsden","sequence":"additional","affiliation":[{"name":"Lipid Peroxidation Unit, Laboratory of Clinical Investigation National Institute on Aging  Baltimore Maryland USA"},{"name":"Intramural Program of the National Institute on Alcohol Abuse and Alcoholism NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412451360"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0952\u20103278(97)90530\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000410\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833821c1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373\u201015.2015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001983"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2020.100046"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2022.101165"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.031"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136380"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417720216"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.04.050"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2017.11.002"},{"key":"e_1_2_10_18_1","unstructured":"National 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