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The research specifically examines the expression levels of these genes in chickens fed diets enriched with varying concentrations of curcumin. The aim is to uncover the potential roles and functions of\n                    <jats:italic>ELOVL<\/jats:italic>\n                    genes in the metabolism of fatty acids (FAs) in this species. In the experimental design, Hy\u2010Line Brown commercial laying hens were selected for a feeding trial lasting 10\u2009weeks. During this period, the hens were fed diets supplemented with curcumin at 100, 200, 300, and 400\u2009mg\/kg. The results revealed several critical insights: (1) It was confirmed that the\n                    <jats:italic>ELOVL<\/jats:italic>\n                    genes in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Gallus gallus<\/jats:italic>\n                    <\/jats:styled-content>\n                    are orthologues of those found in vertebrates, indicating a shared evolutionary lineage; (2) There were noteworthy differences in how\n                    <jats:italic>ELOVL<\/jats:italic>\n                    genes, except\n                    <jats:italic>ELOVL1<\/jats:italic>\n                    and\n                    <jats:italic>ELOVL7<\/jats:italic>\n                    , were distributed across various tissues and how they responded to dietary curcumin, prompting the need for comprehensive promoter analyses to better understand their functions in chickens; (3) The addition of curcumin to the diet did not increase omega\u20103 FAs in egg yolk; and (4) Dietary curcumin modulated\n                    <jats:italic>ELOVL<\/jats:italic>\n                    mRNA transcription in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Gallus gallus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . However, the intricate and multifaceted nature of FA metabolism presents challenges to fully grasping the implications of these results, highlighting the necessity for further in\u2010depth investigations in this area.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70013","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:40:52Z","timestamp":1760420452000},"page":"109-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome\u2010Wide Identification, Characterization, and\u00a0Nutrigenomics of\n                    <scp>\n                      <i>ELOVL<\/i>\n                    <\/scp>\n                    Genes in Laying Hens and Their Responses to Various Levels of Dietary Curcumin"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-1322","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Dumlu","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-3489","authenticated-orcid":false,"given":"\u015eaziye Canan","family":"B\u00f6l\u00fckba\u015fi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-5679","authenticated-orcid":false,"given":"Abdulkadir","family":"Bayir","sequence":"additional","affiliation":[{"name":"Department of Aquaculture, Fisheries Faculty Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Western Caspian University  Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.06.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2018.1489216"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012538"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028451"},{"key":"e_1_2_9_6_1","first-page":"133","article-title":"Ya\u011f Asitlerinin Sa\u011fl\u0131k ve Beslenme \u00dczerine Etkileri","volume":"5","author":"\u00c7akmak\u00e7\u0131 S.","year":"2012","journal-title":"T\u00fcrk Bilimsel Derlemeler Dergisi"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp348"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.02.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-43"},{"key":"e_1_2_9_10_1","first-page":"411","article-title":"Dietary Enrichment of n\u20103 PUFA for Laying Hens: Effect of Different Sources on Production, Composition and Quality of Eggs","volume":"33","author":"Dalle Zotte A.","year":"2015","journal-title":"Animal Science Papers and Reports"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2017.03.029"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew462"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2019.101006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.38.353"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-890-0:571"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.170290"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-8-1312-2297-3.50002-3"},{"key":"e_1_2_9_20_1","first-page":"195","article-title":"Therapeutic Roles of Curcumin: Lessons Learned From Clinical Trials","volume":"13","author":"Gupta S. 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