{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:35:17Z","timestamp":1785497717828,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013220","name":"Ultragenyx Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fatty acid beta\u2010oxidation defects (\n                    <jats:styled-content style=\"fixed-case\">FAOD<\/jats:styled-content>\n                    ) are a subgroup of lipid myopathies with heterogeneous presentations. Clinical presentation may manifest as muscular weakness, cramps, postexercise myalgias, and episodic rhabdomyolysis in children or adults. Our objective was to describe the clinical manifestations, biochemical, anatomopathological, and molecular results in a series of adult patients diagnosed with\n                    <jats:styled-content style=\"fixed-case\">FAOD<\/jats:styled-content>\n                    during adolescence or adulthood at five centers in Argentina. A total of seven patients with carnitine palmitoyltransferase\u20102 (\n                    <jats:styled-content style=\"fixed-case\">CPT II<\/jats:styled-content>\n                    ), very\u2010long\u2010chain acyl\u2010CoA dehydrogenase (\n                    <jats:styled-content style=\"fixed-case\">VLCAD<\/jats:styled-content>\n                    ), and long\u2010chain 3\u2010hydroxyacyl\u2010\n                    <jats:styled-content style=\"fixed-case\">CoA<\/jats:styled-content>\n                    dehydrogenase\n                    <jats:styled-content style=\"fixed-case\">LCHAD<\/jats:styled-content>\n                    deficiency were reported. The definite diagnosis of metabolic myopathies due to FAOD requires an understanding of clinical, biochemical, neurophysiological, and muscular imaging\/biopsy patterns. All patients in this series consulted pediatricians, general practitioners, rheumatologists, and orthopedists for years, underscoring the need to disseminate these presentation patterns across various medical specialties. Early diagnosis and treatment using traditional diets and new pharmacological strategies not only enhance the quality of life, but also improve survival in these patients.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70021","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:40:16Z","timestamp":1762933216000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Chain Fatty Acid Beta\u2010Oxidation Defects: A Case Series and Literature Review"],"prefix":"10.1002","volume":"61","author":[{"given":"Juan","family":"Politei","sequence":"first","affiliation":[{"name":"Neurology Department SPINE Foundation  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Berardo","sequence":"additional","affiliation":[{"name":"Neurology Section Sanatorio Allende Nueva C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Department Hospital Espa\u00f1ol de Rosario  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Nieto","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital General de Agudos Bernardino Rivadavia  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Recchia","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Central de Mendoza  Mendoza 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