{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:28:43Z","timestamp":1773257323719,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["SERB project EEQ\/2021\/000373"],"award-info":[{"award-number":["SERB project EEQ\/2021\/000373"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report hepatic and renal parameters affected by fixed oil from ginger (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Zingiber officinale<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) and black pepper (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Piper nigrum<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) in male Wistar rats. Dyslipidaemia (hyperlipidemia) and diabetes were induced by feeding 35% saturated fat for 30\u2009days, followed by the administration of streptozotocin (28\u2009mg\/kg bw). Rats were grouped into: DD (dyslipidaemia with diabetes), DD\u2009+\u2009M\u2009+\u2009O [metformin (20\u2009mg\/kg bw)\u2009+\u2009orlistat (10\u2009mg\/kg bw)], DD\u2009+\u2009G\u2010FO [ginger fixed oil (50\u2009mg\/kg bw)], DD\u2009+\u2009P\u2010FO [black pepper fixed oil (50\u2009mg\/kg bw)] and control with 60\u2010days feeding. The DD group had significantly elevated lipids (total cholesterol, LDL\u2009+\u2009VLDL cholesterol, and triglycerides), glycaemic parameters (FBS, insulin, HbA1c, and HOMA\u2010IR), organ function enzyme markers (ALP, CK\u2010MB, CK\u2010NAC, SGOT, and SGPT) compared to control (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), whereas experimental groups (DD\u2009+\u2009G\u2010FO and DD\u2009+\u2009P\u2010FO) showed a significant decrease compared to DD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The hepatic levels of caspase\u20103, cytochrome c, and p53 were increased significantly in DD compared to the control and experimental groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Similarly, kidney injury molecule\u20101 (KIM\u20101), in both serum and kidney, was significantly increased in DD compared to the control and experimental groups. The hepatic (bilirubin) and renal (urea, uric acid, and creatinine) markers were elevated significantly in DD compared to the control and experimental groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Liver and kidney histology indicated that DD enhanced lipid accumulation, resulting in tissue damage compared to the control and experimental groups. Thus, we established that fixed oil from ginger and black pepper sustained hepatic and renal function in metabolic abnormalities like hyperlipidemia and diabetes in the experimental rat model.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70022","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:13:01Z","timestamp":1762949581000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ginger (\n                    <scp>\n                      <i>Zingiber officinale<\/i>\n                    <\/scp>\n                    ) and Black Pepper (\n                    <scp>\n                      <i>Piper nigrum<\/i>\n                    <\/scp>\n                    ) Fixed Oil Sustain Hepatic and Renal Function: Insight From a Metabolic Disorder Rat Model"],"prefix":"10.1002","volume":"61","author":[{"given":"Manasa Hassan","family":"Yashwanthkumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore Karnataka India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha Manmohan","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Food Safety Analysis and Quality Control CSIR\u2010Central Food Technological Research Institute  Mysore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Kumar","family":"Somashekher","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-0123","authenticated-orcid":false,"given":"Ajay","family":"Tumaney","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Life Sciences, University of Hyderabad  Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramaprasad Ravichandra","family":"Talahalli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore Karnataka India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101074578"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hnm.2020.200111"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-90794-1.00015-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408391003624848"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u2010500x.119726"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010021\u201005036\u20101"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.7.1340"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v32i4.6617"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(68)90041\u20107"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021\u20109258(18)64849\u20105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257\u2010009\u20103037\u20109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7458"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399819666230328151108"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo01349g"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.101574"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.03.016"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2016.12.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(60)90035\u20108"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75016-3_1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10496475.2012.680548"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2004.09.001"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390601062054"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114520002445"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010021\u201000519\u2010y"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lipd.70022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:21:13Z","timestamp":1773195673000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1002\/lipd.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/lipd.70022"],"URL":"https:\/\/doi.org\/10.1002\/lipd.70022","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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