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A cohort of 11 newly diagnosed\n SAA<\/jats:styled-content>\n patients and 15 healthy controls were enrolled between June 2020 and November 2022, and six of the\n SAA<\/jats:styled-content>\n patients received\n ATG<\/jats:styled-content>\n \u2010based\n IST<\/jats:styled-content>\n .\n PB<\/jats:styled-content>\n and\n BM<\/jats:styled-content>\n serum were collected for further\n LC<\/jats:styled-content>\n \u2013\n MS<\/jats:styled-content>\n \/\n MS<\/jats:styled-content>\n analysis. Compared to donors,\n SAA<\/jats:styled-content>\n patients exhibited more pronounced abnormalities in lipid metabolism profiles within\n BM<\/jats:styled-content>\n serum relative to\n PB<\/jats:styled-content>\n serum. Specifically, elevated levels of free fatty acids (\n FA<\/jats:styled-content>\n ), fatty acid esters of hydroxyl fatty acids (\n FAHFA<\/jats:styled-content>\n ), and phosphatidylserine (\n PS<\/jats:styled-content>\n ) were noted in the\n BM<\/jats:styled-content>\n serum of\n SAA<\/jats:styled-content>\n patients. Following treatment, there was a noted increase in acylcarnitine (\n ACar<\/jats:styled-content>\n ), hexosylceramide non\u2010hydroxy fatty acid\u2010sphingosine (\n HexCer<\/jats:styled-content>\n \u2010\n NS<\/jats:styled-content>\n ), and sulfur hexosyl ceramide hydroxy fatty acid (\n SHexCer<\/jats:styled-content>\n ), while levels of lysophosphatidylcholine (\n LPC<\/jats:styled-content>\n ) and oxidized phosphatidylcholine (\n OxPC<\/jats:styled-content>\n ) diminished, particularly in complete or partial response (\n CR<\/jats:styled-content>\n \/\n PR<\/jats:styled-content>\n ) patients. Acknowledging the changes of\n BM<\/jats:styled-content>\n lipidomics may contribute to earlier prediction of\n ATG<\/jats:styled-content>\n \u2010based\n IST<\/jats:styled-content>\n response in\n SAA<\/jats:styled-content>\n patients.\n <\/jats:p>","DOI":"10.1002\/lipd.70034","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:35:42Z","timestamp":1768872942000},"page":"347-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response"],"prefix":"10.1002","volume":"61","author":[{"given":"Zexing","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Zhejiang Hangzhou China"},{"name":"The First 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Traditional Chinese Medicine Clinical Research Base (Hematology) Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-0848","authenticated-orcid":false,"given":"Yingying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Zhejiang Hangzhou China"},{"name":"The First School of Clinical Medicine Zhejiang Chinese Medical University Zhejiang Hangzhou China"},{"name":"National Traditional Chinese Medicine Clinical Research Base (Hematology) Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Zhejiang Hangzhou 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Zhejiang Hangzhou China"},{"name":"The First School of Clinical Medicine Zhejiang Chinese Medical University Zhejiang Hangzhou China"},{"name":"National Traditional Chinese Medicine Clinical Research Base (Hematology) Zhejiang Hangzhou China"},{"name":"Department of Oncology and Hematology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medicine University Zhejiang 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