{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:30Z","timestamp":1786978170752,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive endocrine condition in women, with implications in fertility and long\u2010term metabolic health. PCOS with hyperandrogen (HA\u2010PCOS; hyperandrogenic PCOS) has been recently identified as one of the four subtypes of PCOS. Dyslipidemia is known to be associated with clinical hyperandrogenism in PCOS. Indeed, patients with HA\u2010PCOS were found to have the highest incidence of dyslipidemia among patients with the other three subtypes of PCOS. In the present study, we identified genes involved in lipid\u2010associated processes (namely, lipid biosynthetic process, lipid catabolic process, hyperlipidemia, hypolipidemia and lipid homeostasis) whose expression are changed in granulosa cells from HA\u2010PCOS patients compared to those from non\u2010PCOS women, in order to identify molecular factors contributing to the highest risk of dyslipidemia incidence observed in patients with hyperandrogenic PCOS. We found 27 lipid biology\u2010associated genes (ACSM1, ACSM3, AGPAT4, AJUBA, ALDH1A2, CCDC3, LPL, P2RX1, PITPNM1, PRLR, PTGIS, SLC44A5, SPTSSB, ST8SIA5, IDH1, ITPKA, PPM1L, SPTLC2, ADRA2A, ASPG, IRS1, PLB1, IDH1, LCT, NUDT8, SMPDL3A and SYNE2) whose transcript levels are significantly downregulated or upregulated in granulosa cells of women with HA\u2010PCOS compared to those in control women. The majority of these genes have not been previously studied in the context of PCOS, and are possible candidates for further research to better understand the contribution of high androgen levels to dyslipidemia in PCOS. Targeting of high androgen\u2010induced dyslipidemia might be of high clinical importance in the treatment of women with HA\u2010PCOS.<\/jats:p>","DOI":"10.1002\/lipd.70035","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:28:25Z","timestamp":1769642905000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regulation of Lipid Biology\u2010Associated Gene Expression in Granulosa Cells in Hyperandrogenic\n                    <scp>PCOS<\/scp>\n                    : A Possible Link Between Dyslipidemia and Hyperandrogenism"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-5157","authenticated-orcid":false,"given":"Caglar","family":"Berkel","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Tokat Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010023\u201001280\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010024\u201001643\u20103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.70161"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad356"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116673197"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513591003649823"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.07.004"},{"key":"e_1_2_8_9_1","unstructured":"Gao X. S.Zhao Y.Du et\u00a0al.2025. \u201cData\u2010Driven Subtypes of Polycystic Ovary Syndrome and Their Association With Clinical Outcomes. Erratum in: Nat Med. 2025;31(12):4314.\u201d31 no.12:4214\u20134224.https:\/\/doi.org\/10.1038\/s41591\u2010025\u201003984\u20101."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.892125"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010024\u201001057\u2010w"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(22)00163\u20102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2022.543499.1228"},{"key":"e_1_2_8_14_1","unstructured":"Kassambara A.2023.\u201c_ggpubr: \u2018ggplot2\u2019 Based Publication Ready Plots_.\u201dR Package Version 0.6.0.https:\/\/CRAN.R\u2010project.org\/package=ggpubr."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1190934"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.815968"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010014\u20100092\u20104"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17950"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2019.05.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20101290"},{"key":"e_1_2_8_23_1","unstructured":"Ooms J.2023.\u201c_magick: Advanced Graphics and Image\u2010Processing in R_.\u201dR Package Version 2.8.2.https:\/\/CRAN.R\u2010project.org\/package=magick."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1650343"},{"key":"e_1_2_8_25_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.44"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7781823"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_13_23"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010024\u201000511\u20103"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"issue":"10","key":"e_1_2_8_31_1","first-page":"17451","article-title":"Insulin Receptor Substrate\u20101 (IRS\u20101) rs1801278G>A Polymorphism Is Associated With Polycystic\u00a0Ovary Syndrome Susceptibility: A Meta\u2010Analysis","volume":"8","author":"Tang W.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei205"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062951\u2010z"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_8_35_1","unstructured":"Wickham H. J.Hester andJ.Bryan.2023.\u201c_readr: Read Rectangular Text Data_.\u201dR Package Version 2.1.4.https:\/\/CRAN.R\u2010project.org\/package=readr."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111141"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201019209\u2010x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010024\u201001806\u2010w"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010014\u20100119\u20106"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.10.038"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202304_32097"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010025\u201001841\u2010w"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lipd.70035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:47:36Z","timestamp":1778042856000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1002\/lipd.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/lipd.70035"],"URL":"https:\/\/doi.org\/10.1002\/lipd.70035","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}