{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:13:36Z","timestamp":1778044416606,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Atat\u00fcrk \u00dcniversitesi","doi-asserted-by":"publisher","award":["FDK\u20102022\u201010825"],"award-info":[{"award-number":["FDK\u20102022\u201010825"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, five\n                    <jats:italic>FADS<\/jats:italic>\n                    genes\u2014\n                    <jats:italic>FADS1a, FADS1b, FADS1c, FADS2<\/jats:italic>\n                    , and\n                    <jats:italic>FADS6<\/jats:italic>\n                    \u2014were cloned and characterized in chickens. Their nutritional regulations by diets containing various levels (100, 200, 300, and 400\u2009mg\/kg) of curcumin (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) were also determined. We aimed to determine the functions of\n                    <jats:italic>FADS<\/jats:italic>\n                    genes in fatty acid (FA) metabolism in chickens. We identified two critical conserved regions in chicken FADS: DWXXGH and GEXA, likely conferring structural stability to the iron\u2010binding center and modulating the electrostatic potential. The chicken\n                    <jats:italic>FADS<\/jats:italic>\n                    genes are orthologs of vertebrate\n                    <jats:italic>FADS<\/jats:italic>\n                    genes.\n                    <jats:italic>FADS1a\/FADS1b<\/jats:italic>\n                    and\n                    <jats:italic>FADS1c<\/jats:italic>\n                    exhibited markedly different tissue\u2010specific transcription. However,\n                    <jats:italic>FADS1a<\/jats:italic>\n                    ,\n                    <jats:italic>FADS1b<\/jats:italic>\n                    , and\n                    <jats:italic>FADS1c<\/jats:italic>\n                    responded differently to dietary curcumin, suggesting their functional divergence. Therefore, we propose that\n                    <jats:italic>FADS1a, FADS1b<\/jats:italic>\n                    , and\n                    <jats:italic>FADS1c<\/jats:italic>\n                    were retained in the chicken genome due to neo\u2010 or sub\u2010functionalization. Dietary curcumin upregulated four of five chicken\n                    <jats:italic>FADS<\/jats:italic>\n                    genes (except\n                    <jats:italic>FADS1a<\/jats:italic>\n                    ), indicating its effect on FA metabolism in chickens. Analyzing the promoter regions of\n                    <jats:italic>FADS1<\/jats:italic>\n                    genes is essential for identifying their regulatory mechanisms, which may explain their evolutionary fates and functions.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70036","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T03:00:16Z","timestamp":1771383616000},"page":"427-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Cloning, Characterization, Tissue\u2010Specific Transcription, and Nutritional Regulation of\n                    <i>FADS<\/i>\n                    Genes by Dietary Curcumin in Chicken,\n                    <i>Gallus gallus<\/i>"],"prefix":"10.1002","volume":"61","author":[{"given":"B\u00fc\u015fra","family":"Dumlu","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eaziye Canan","family":"B\u00f6l\u00fckba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-5679","authenticated-orcid":false,"given":"Abdulkadir","family":"Bay\u0131r","sequence":"additional","affiliation":[{"name":"Department of Aquaculture, Fisheries Faculty Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Western Caspian University  Baku Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1176934320913255"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042731"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1082"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5194\/aab\u201066\u2010121\u20102023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.155259"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp348"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2016.01.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2017.03.029"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1374"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.70013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00209a008"},{"key":"e_1_2_9_13_1","volume-title":"The Proteomics Protocols Handbook. 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