{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:08:25Z","timestamp":1791655705620,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dyslipidemia is a key comorbidity in prediabetes and type 2 diabetes (T2D). Curcumin, from turmeric, may improve lipid levels, but evidence is inconsistent. This meta\u2010analysis evaluates its efficacy on lipid profiles in this population. We searched PubMed, Web of Science, and Scopus until August 2025 for RCTs on curcumin\/turmeric in adults with prediabetes\/T2DM. Data on lipids (triglycerides, total cholesterol, LDL\u2010C, HDL\u2010C) were pooled using a random\u2010effects model, expressed as weighted mean differences (WMD) with 95% confidence intervals (CIs). Twenty\u2010seven RCTs (31 arms) were included. Curcumin\/turmeric supplementation significantly reduced triglycerides (WMD: \u221213.73\u2009mg\/dL; 95% CI: \u221219.49, \u22127.96), total cholesterol (WMD: \u22125.24\u2009mg\/dL; 95% CI: \u22129.42, \u22121.07), and LDL\u2010C (WMD: \u22125.72\u2009mg\/dL; 95% CI: \u22128.62, \u22122.82) and increased HDL\u2010C (WMD: 2.14\u2009mg\/dL; 95% CI: 1.08, 3.20). Effects on apolipoproteins were non\u2010significant. Significant heterogeneity was observed (I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt;\u200980%). Subgroup analyses indicated greater benefits in diabetic patients, those with higher baseline lipids, and with specific formulations. The certainty of evidence (GRADE) was low for all outcomes. Curcumin\/turmeric supplementation yields modest improvements in the lipid profile of individuals with prediabetes and diabetes. However, significant heterogeneity and low certainty of evidence limit the robustness and clinical applicability of these findings. Therefore, the results should be interpreted with caution. Future trials should prioritize enhanced formulations and longer durations.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70037","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T02:35:10Z","timestamp":1770604510000},"page":"381-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Curcumin\/Turmeric Supplementation on Lipid Profile in Subjects With Prediabetes and Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-2713","authenticated-orcid":false,"given":"Hossein","family":"Bahari","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Malekahmadi","sequence":"additional","affiliation":[{"name":"Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6526-8712","authenticated-orcid":false,"given":"Mostafa","family":"Shahraki Jazinaki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Asadi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Soltaninejad","sequence":"additional","affiliation":[{"name":"School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haniyeh","family":"Golafrouz","sequence":"additional","affiliation":[{"name":"Rajaei Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6312"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6328"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020404"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00274-6"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4469"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119558378"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.051"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020684"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.09.013"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01916-7"},{"issue":"1","key":"e_1_2_13_12_1","first-page":"S179","article-title":"Cardiovascular Disease and Risk Management: Standards of Care in Diabetes\u20142024","volume":"47","author":"Committee ADAPP","year":"2023","journal-title":"Diabetes Care"},{"issue":"3","key":"e_1_2_13_13_1","first-page":"111","article-title":"How Combined and Separate Aerobic Training and Turmeric Supplementation Alter Lipid Profile and Glycemic Status? 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