{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:24:44Z","timestamp":1792106684148,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024A03J1259"],"award-info":[{"award-number":["2024A03J1259"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to evaluate whether the neutrophil\u2010to\u2010high\u2010density lipoprotein cholesterol ratio (NHR) is independently associated with Insulin Resistance (IR) among individuals with obesity and to examine the robustness of this association across distinct populations. Two independent cohorts were analyzed: a Chinese training cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009764) and a US validation cohort from the National Health and Nutrition Examination Survey (NHANES;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092963). Multivariable logistic regression and restricted cubic spline (RCS) models were applied to assess associations between NHR and IR. Subgroup analyses evaluated consistency, and receiver operating characteristic (ROC) curves assessed predictive performance. NHR was positively associated with IR in both cohorts. After full adjustment, each unit increase in NHR was associated with a 23% higher IR risk in the training cohort (OR\u2009=\u20091.23, 95% CI: 1.10\u20131.38) and a 21% higher risk in the validation cohort (OR\u2009=\u20091.21, 95% CI: 1.09\u20131.35). Participants in the highest NHR quartile had markedly increased IR risk compared with the lowest quartile (training: OR\u2009=\u20094.45, 95% CI: 2.27\u20138.69; validation: OR\u2009=\u20092.04, 95% CI: 1.37\u20133.03). RCS analysis indicated a linear association in the training cohort and a nonlinear pattern in the validation cohort. Associations were consistent across subgroups. NHR showed modest predictive ability (AUC: 0.677 and 0.654). NHR demonstrated a significant positive association with insulin resistance in Chinese and US obese cohorts, indicating its potential utility as a biomarker for IR and associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70049","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:36:17Z","timestamp":1773156977000},"page":"493-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Neutrophil\u2010To\u2010\n                    <scp>HDL<\/scp>\n                    Cholesterol Ratio and Insulin Resistance in Individuals With Obesity: Cross\u2010Sectional Study of Chinese and\n                    <scp>U.S.<\/scp>\n                    Cohorts"],"prefix":"10.1002","volume":"61","author":[{"given":"Zhenguang","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenpeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-8045","authenticated-orcid":false,"given":"Bingsheng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lvjia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-7910","authenticated-orcid":false,"given":"Wenfu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Gastrointestinal Surgery, Dongguan East Central Hospital Sixth Affiliated Hospital of Jinan University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2900-095X","authenticated-orcid":false,"given":"Jingge","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery First Affiliated Hospital of Jinan University  Guangzhou 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