{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:14:08Z","timestamp":1789168448083,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity induced by a high\u2010calorie diet (HCD) results in the accumulation of ectopic fat in tissues not typically associated with lipid storage. This accumulation can cause lipotoxicity, a type of cellular stress triggered by the accumulation of lipid intermediates such as diacylglycerols (DAG) and ceramides (Cer) in nonadipose tissues like the liver. The accumulation of these bioactive lipids has been directly linked to the development of insulin resistance induced by a HCD. However, the specific molecular species of lipids associated with such metabolic abnormalities remain poorly defined. In this study, we conducted a systematic review and meta\u2010analysis to consolidate current evidence on how HCDs alter the liver lipidome in rodents. A search was performed in PubMed to identify lipidomic studies on the livers of mice (C57Bl\/6) and rats (Wistar and Sprague\u2013Dawley) fed high\u2010calorie diets. We assessed the effect size by calculating the standardized mean difference (SMD) using Hedges' g with a 95% confidence interval. A total of 18 studies were identified. The HCD had a significant effect on insulin resistance (HOMA\u2010IR,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and significantly increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) hepatic levels of Cer(18:0_18:0), Cer(18:1_18:0), Cer(18:1_20:0), Cer(18:2_20:0), and DAG(16:0_18:1) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore, the HCD negatively affected three specific phosphatidylcholine (PC) species and four phosphatidylethanolamine (PE) species containing monounsaturated and polyunsaturated fatty acid chains. These findings may provide valuable insights for targeting the molecular mechanisms underlying tissue\u2010specific insulin resistance, a significant condition in the context of obesity.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70061","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:19:14Z","timestamp":1777443554000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic Lipids as Molecular Targets in Obesity\u2010Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-6405","authenticated-orcid":false,"given":"Rogelio I.","family":"Servin\u2010Uribe","sequence":"first","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Quer\u00e9taro  Quer\u00e9taro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-4558","authenticated-orcid":false,"given":"Jara","family":"P\u00e9rez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Nutrition Institute of Food Science, Technology and Nutrition (ICTAN\u2010CSIC)  Madrid Spain"},{"name":"CIBER Diabetes and Associated Metabolic Diseases: Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) Carlos III Health Institute (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Casta\u00f1o Tostado","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Quer\u00e9taro  Quer\u00e9taro 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