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To investigate depot\u2010specific metabolic adaptations in subcutaneous (SAT) and epididymal adipose tissue (EAT) in response to chia oil supplementation. Male C57BL\/6J mice received a control diet (C group) or a high\u2010fat diet (H group) for 8\u2009weeks, followed by 5\u2009weeks of chia oil supplementation (1.5% w\/w; 1.5\u2009g\/100\u2009g diet; CC and HC groups). Exometabolomic profiling of SAT and EAT explants was performed using\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR, accompanied by targeted gene\u2010expression analyses. Chia oil supplementation reduced adipocyte hypertrophy and improved glucose tolerance in obese mice without altering body or adipose tissue mass. Obesity markedly decreased\n                    <jats:sc>l<\/jats:sc>\n                    \u2010histidine secretion in SAT and this effect was not modified by chia oil supplementation. In obese SAT, chia oil reduced\n                    <jats:sc>l<\/jats:sc>\n                    \u2010valine and\n                    <jats:sc>l<\/jats:sc>\n                    \u2010proline secretion and increased\n                    <jats:sc>l<\/jats:sc>\n                    \u2010threonine levels, while it increased lactate secretion in obese EAT. Obesity did not significantly affect acetate secretion, although chia oil supplementation resulted in a depot\u2010specific variation exclusively in the HC group. Correlation analysis revealed that chia oil modified metabolic interaction networks in both adipose depots. Chia oil supplementation induced depot\u2010specific metabolic adjustments in SAT and EAT, highlighting the plasticity of adipose tissue and the potential of dietary lipids to modulate adipose metabolic networks.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70066","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:31:11Z","timestamp":1780277471000},"page":"675-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-2267","authenticated-orcid":false,"suffix":"Jr","given":"Gilson Costa","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Metabol\u00f4mica, Departamento de Gen\u00e9tica Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-3689","authenticated-orcid":false,"given":"Agatha","family":"Assis\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Celular e Molecular, Departamento de Biologia Celular Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9755-3166","authenticated-orcid":false,"given":"Gabrielly","family":"Muniz\u2010Cassuce","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Celular e Molecular, Departamento de Biologia Celular Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-0218","authenticated-orcid":false,"given":"Tatiana","family":"El Bacha","sequence":"additional","affiliation":[{"name":"N\u00facleo de Estudos Com Bioativos, Mitoc\u00f4ndria e Metabolismo da Placenta, Instituto de Nutri\u00e7\u00e3o Josu\u00e9 de Castro Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-4401","authenticated-orcid":false,"given":"Christina","family":"Barja\u2010Fidalgo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Celular e Molecular, Departamento de Biologia Celular Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-2517","authenticated-orcid":false,"given":"Simone","family":"Vargas da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Celular e Molecular, Departamento de Biologia Celular Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro  Rio de Janeiro 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2026.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lipd.70066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lipd.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:57:39Z","timestamp":1794358659000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1002\/lipd.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/lipd.70066"],"URL":"https:\/\/doi.org\/10.1002\/lipd.70066","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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