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UK Biobank is a large cohort study that includes data on plasma omega\u20103 fatty acids at study entry and health outcomes during the follow\u2010up period. The aim of this research is to explore the association between plasma omega\u20103 fatty acids (total omega\u20103 fatty acids, docosahexaenoic acid (DHA) and non\u2010DHA omega\u20103 fatty acids) and cardiometabolic health outcomes by systematically reviewing publications from UK Biobank. Three databases (EMBASE, MEDLINE, CINAHL) were searched in September 2025 using key words. Based on inclusion\/exclusion criteria, 16 publications were selected for inclusion (two cross\u2010sectional and 14 longitudinal with a follow\u2010up of 11 to 14\u2009years). Sample size varied between 20,338 and 273,834 across the included studies. Eleven studies reported on CVD outcomes and five on metabolic outcomes. Plasma total omega\u20103 fatty acids and DHA were inversely associated with risk of coronary heart disease, CVD mortality, heart failure, haemorrhagic stroke and severe fatty liver disease. Plasma total omega\u20103 fatty acids were also inversely associated with risk of prediabetes and type\u20102 diabetes, while plasma DHA was also inversely associated with risk of coronary heart disease mortality, ischemic stroke and fatty liver disease. It is concluded that publications based on UK Biobank consistently demonstrate a significant association between higher levels of total omega\u20103 fatty acids or DHA in plasma and lower likelihood of poor cardiometabolic health outcomes, providing support for guidance for the population to achieve recommended intakes of these fatty acids.<\/jats:p>","DOI":"10.1002\/lipd.70076","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:01:05Z","timestamp":1785326465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating Omega\u20103 Fatty Acids and Cardiometabolic Outcomes: A Systematic Review of Publications From\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1002","author":[{"given":"Warda Tul","family":"Firdous","sequence":"first","affiliation":[{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton  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