{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:15Z","timestamp":1786115895278,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This review explores how the fatty acid (FA) profile of the Amazonian\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Rhynchophorus palmarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    larva (Chontacuro), traditionally eaten for respiratory ailments, might biochemically mitigate viral respiratory infections. During metamorphosis, this insect utilizes its unique FA matrix to survive severe, self\u2010inflicted oxidative and inflammatory tissue stress. The authors hypothesize that when consumed by humans, these insect lipids undergo chylomicron\u2010mediated lymphatic transport. This pathway bypasses initial liver metabolism, delivering unsaturated FAs directly to the pulmonary microvasculature and alveolar macrophages in the lungs. Once there, the FAs are proposed to act via two main mechanisms: One is inflammation resolution, where the \u03c9\u20103 fraction is hypothesized to be metabolized via the 15\u2010LOX enzyme pathway into Specialized Pro\u2010Resolving Mediators (SPMs) and activate PPAR\u2010\u03b1, potentially shifting the immune response from chronic inflammation toward active tissue repair. The other is viral sabotage: The highly unsaturated fats increase cell membrane fluidity, destabilizing the \u201clipid rafts\u201d that viruses rely on for cellular entry and assembly. While in\u00a0vitro and\n                    <jats:italic>in silico<\/jats:italic>\n                    models suggest a synergistic \u201ccocktail effect\u201d that primes and then resolves the immune response, the authors note that direct human clinical evidence is currently lacking.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70077","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:11:18Z","timestamp":1785996678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resolution\u2010Oriented Immunopharmacological Potential of the Lipid Matrix of\n                    <scp>\n                      <i>Rhynchophorus palmarum<\/i>\n                    <\/scp>\n                    Larvae in Viral Respiratory Infections: A Perspective Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-7536","authenticated-orcid":false,"given":"W. D.","family":"Lituma\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Siddha Vetha Multiversity  New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-4825","authenticated-orcid":false,"given":"C.","family":"Casella","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-8679","authenticated-orcid":false,"given":"S. J.","family":"Ballaz","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Esp\u00edritu Santo  Samborond\u00f3n Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13210"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0334211100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.21723"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3920\/JIFF2022.0033"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1505S"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15071027"},{"key":"e_1_2_13_8_1","volume-title":"Edible Insects","author":"Cartay R.","year":"2020"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2024.106507"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md23040154"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.14237\/ebl.10.1.2019.1271"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009127"},{"issue":"4","key":"e_1_2_13_13_1","first-page":"89","article-title":"Fatty Acid Composition and Properties of Skin and Digestive Fat Content Oils From \n                     Rhynchophorus palmarum\n                   L. 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