{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:16:04Z","timestamp":1788232564235,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370428"],"award-info":[{"award-number":["82370428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400278"],"award-info":[{"award-number":["82400278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Background and AimsThe relationship between blood lipids and atrial fibrillation (AF) remains unclear. Nuclear magnetic resonance (NMR) spectroscopy enables the profiling of size\u2010defined lipoproteins and their contained lipid components. This study aimed to analyze the genetic causal relationships between lipoproteins, NMR\u2010measured lipids, and AF, providing insights into the prediction and treatment of AF. Methods and Results. Summary\u2010level data on lipoprotein and lipid concentrations measured by NMR were obtained from the UK Biobank. Summary\u2010level data on AF were sourced from the FinnGen project. Mendelian Randomization (MR) analysis using inverse\u2010variance weighting was employed as the primary analytical method. Genetically predicted elevated low\u2010density lipoprotein (LDL) cholesterol, LDL free cholesterol, LDL phospholipids, and LDL total lipids measured by NMR were associated with an increased risk of AF. MR analyses did not identify robust causal associations between lipids contained in high\u2010density lipoproteins (HDL), intermediate\u2010density lipoproteins (IDL), or very\u2010low\u2010density lipoproteins (VLDL) and AF. Among size\u2010defined LDL particles, elevated lipids of large LDL (L\u2010LDL) were strongly associated with increased risk of AF. Hypertension and coronary heart disease mediated these effects. Genetic variation alleles at\n                    <jats:italic>ABCG5<\/jats:italic>\n                    ,\n                    <jats:italic>LDLR<\/jats:italic>\n                    , and\n                    <jats:italic>PCSK9<\/jats:italic>\n                    genes, which reduce lipid levels, were associated with lower risk of AF. Conclusions Increased lipids contained in LDL were associated with elevated risk of AF. L\u2010LDL particles exhibited a clear association with increased AF risk. LDL is identified as a critical lipoprotein for predicting and treating AF.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70080","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:05:30Z","timestamp":1788231930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causal Effects of Lipoproteins and Lipids on Atrial Fibrillation: A Mendelian Randomization Study"],"prefix":"10.1002","author":[{"given":"Shuo","family":"Liu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 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University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Ming","family":"Fu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhuji People's Hospital of Zhejiang Province Zhuji Affiliated Hospital of Shaoxing University  Zhuji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 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