{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:23:54Z","timestamp":1787790234014,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study investigated the effects of Yinchen lipid\u2010lowering tea (YCLLT) in a rat model of hyperlipidemia. A hyperlipidemic rat model was established using a high\u2010fat diet. After 60\u2009days of low\u2010, middle\u2010, and high\u2010dose YCLLT intragastric administration, body weight, serum total cholesterol (TC), serum triglyceride (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDL\u2010C), liver TC, liver TG and small intestinal niemann\u2010Pick C1\u2010Like 1 (NPC1L1), apolipoprotein B\u201048 (ApoB48), and cholesterol acyltransferase 2 (ACAT2) protein expression were measured. The pathological changes of the liver were observed under a light microscope. Compared with the model group, high\u2010dose YCLLT significantly decreased serum TC, TG and LDL\u2010C levels, and elevated high\u2010density lipoprotein cholesterol (HDL\u2010C). Hepatic TC and TG levels were also significantly decreased. Histopathological analysis showed that YCLLT alleviated hepatocellular steatosis and degenerative injury in hyperlipidemic rats. Immunohistochemistry showed that YCLLT significantly downregulated the protein expression of NPC1L1, ApoB48 and ACAT2. Furthermore, serum ApoB48 levels were significantly reduced in all YCLLT\u2010treated groups and positively correlated with serum TG, TC, and LDL\u2010C. In conclusion, these findings demonstrate that YCLLT exerts potent lipid\u2010lowering and liver\u2010protective effects in hyperlipidemic rats, supporting its potential use as a dietary intervention for the management of hyperlipidemia in the future.<\/jats:p>","DOI":"10.1002\/lipd.70083","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:07:15Z","timestamp":1787789235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>Yinchen Tea Ameliorates Hyperlipidemia in Rats Through Hepatic and Intestinal Lipid Lowering<\/scp>"],"prefix":"10.1002","author":[{"given":"Xilin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7122-1954","authenticated-orcid":false,"given":"Yinjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11100690"},{"key":"e_1_2_12_4_1","first-page":"64","article-title":"Effect of Yinchenhaotang on ALT, AST and TBIL in Patients With Liver Injury Caused by Postoperative Chemotherapy for Breast Cancer","volume":"31","author":"Chang Y.","year":"2019","journal-title":"Tianjin Pharmacy"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.058"},{"key":"e_1_2_12_6_1","first-page":"47","article-title":"Effective Observation on Treating Nonalcoholic Fatty Liver Disease in the Elderly With the Yinchenhao Decoction Plus Clostridium Butyricu","volume":"12","author":"Chen Z.","year":"2020","journal-title":"Clinical Journal of Chinese Medicine"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.29181"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500269102"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2015.01.005"},{"key":"e_1_2_12_10_1","first-page":"1340","article-title":"The Prevention and Treatment Effect of Yin\u2010Chen\u2010Hao Decoction on Concanavalin A \u2010Induced Acute Mice Hepatitis by Inhibiting the Activation of Kupffer Cells","volume":"25","author":"Hu X.","year":"2014","journal-title":"Journal of Li\u2010Shizhen Traditional Chinese Medicine"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1001778"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.10.111"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0022-2275(20)32360-9","article-title":"Differential Expression of ACAT1 and ACAT2 Among Cells Within Liver, Intestine, Kidney, and Adrenal of Nonhuman Primates","volume":"41","author":"Lee R. 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