{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:39:57Z","timestamp":1792589997167,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100475"],"award-info":[{"award-number":["82100475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC0543"],"award-info":[{"award-number":["2026NSFSC0543"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC0617"],"award-info":[{"award-number":["2023NSFSC0617"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aocs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lipids"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The key pathogenesis of atherosclerosis is lipid disorders resulting from aberrant liver metabolism and release of lipids into the bloodstream, leading to endothelial damage and deposition of lipids beneath the endothelial layer. Currently, there exists a limited amount of information pertaining to alterations in liver and blood lipid metabolism. This study aimed to examine the lipid profile associated with the liver and plasma of\n                    <jats:italic>ApoE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice.\n                    <jats:italic>ApoE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice were selected because one high\u2010fat dietary challenge produces aortic lesions and hepatic steatosis in the same animal, allowing plaque and hepatic lipid disturbance to be sampled together. Mice were randomly divided into a normal diet (ND) group and a high\u2010fat diet (HFD) group. To validate the atherosclerosis model, histopathologic analysis techniques such as HE stain, Oil Red O stain, and Masson stain were employed. The lipid profile in both liver and plasma was evaluated using UHPLC\u2010Q Exactive plus MS, utilizing positive and negative ionization modes. In comparison to the ND group, the HFD group exhibited elevated levels of lipid deposition, plaque area, and collagen fiber. Specifically, the liver contained 40 distinct lipids, while the plasma contained 177 distinct lipids. Further examination demonstrated that 11 distinct lipids exhibited differential content in both the liver and plasma. This study demonstrated the existence of a comprehensive lipid profile in the liver and plasma of atherosclerotic mice, with a particular emphasis on PC and TG, which may provide a new biomarker and a better understanding of the molecular mechanisms underlying atherosclerosis.\n                  <\/jats:p>","DOI":"10.1002\/lipd.70089","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:50:35Z","timestamp":1792587035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipidomics Analysis Reveals That Lipid Profile Is Associated With the Liver and Plasma in\n                    <scp>\n                      <i>ApoE<\/i>\n                    <\/scp>\n                    <sup>\n                      <i>\u2212\/\u2212<\/i>\n                    <\/sup>\n                    Atherosclerotic Mice"],"prefix":"10.1002","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Hongqiao International Institute of Medicine Tongren Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xie","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Tang","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-0683","authenticated-orcid":false,"given":"Shasha","family":"Xing","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"1","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/agronomy10010024","article-title":"Natural Variation in Fatty Acid Composition of Diverse World Soybean Germplasms Grown in China","volume":"10","author":"Abdelghany A. 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