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Building on existing resources in the cystic fibrosis (CF) community, the Cystic Fibrosis Learning Network (CFLN) was designed to improve medical outcomes and quality of life through an intentional focus on achieving reliable evidence\u2010based chronic care delivery and creating a system for data\u2010driven collaborative learning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the development and growth of the CFLN considering six domains of a Network Maturity Grid: system leadership; governance and policy management; quality improvement (QI); engagement and community building; data and analytics; and research. We illustrate the impact of the CFLN experience on chronic care processes and indicators of collaborative infrastructure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CFLN represents 36 accredited care centers in the CF Foundation Care Center Network caring for over 6300 patients. Of 6779 patient clinical care visits\/quarter, 77% are entered into the CF Foundation Patient Registry within 30\u2009days, providing timely means to track outcomes. Collaborative visit planning is occurring in 93% of clinical care visits to share agenda setting with patients and families. Almost all CFLN teams (94%, n\u00a0=\u00a034) have a patient\/family partner (PFP), and 74% of PFPs indicate they are actively participating, taking ownership of, or leading QI initiatives with the interdisciplinary care team. In 2022, 97% of centers reported completing 1\u201313 improvement cycles per month, and 82% contributed to monthly QI progress reports to share learning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CFLN is a maturing, collaborative infrastructure. CFLN centers practice at an advanced level of coproduction. The CFLN fosters interdisciplinary and PFP leadership and the performance of consistent data\u2010driven improvement cycles. CFLN centers are positioned to respond to rapid changes in evidence\u2010based care and advance the practice of QI and implementation science on a broader scale.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lrh2.10354","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:46:59Z","timestamp":1671522419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Establishing a Cystic Fibrosis Learning Network: Interventions to promote collaboration and data\u2010driven improvement at scale"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-684X","authenticated-orcid":false,"given":"Thida","family":"Ong","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics University of Washington, Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Albon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Internal Medicine UVA  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raouf S.","family":"Amin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna","family":"Bailey","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srujana","family":"Bandla","sequence":"additional","affiliation":[{"name":"James M. Anderson Center for Health Systems Excellence Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Britto","sequence":"additional","affiliation":[{"name":"James M. Anderson Center for Health Systems Excellence Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Flath","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breck","family":"Gamel","sequence":"additional","affiliation":[{"name":"Children's Health Pediatric Cystic Fibrosis Center Dallas UTSW  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Powers","sequence":"additional","affiliation":[{"name":"Pediatrics Doernbecher Children's Hospital OHSU  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Sabadosa","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K.","family":"Saulitis","sequence":"additional","affiliation":[{"name":"Adult and Pediatric Cystic Fibrosis Care Centers Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacrecia K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Center Children's of Alabama Children's of Alabama  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Thurmond","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-9263","authenticated-orcid":false,"given":"Michael","family":"Seid","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine, Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Cystic Fibrosis Learning Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201511\u2010781OC"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.08.028"},{"key":"e_1_2_9_4_1","unstructured":"Foundation CF.CF Foundation estimates increase in CF population. 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