{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:59:44Z","timestamp":1753869584213,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Learning Health Systems"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This project demonstrates the feasibility of connecting medical imaging data and features, SARS\u2010CoV\u20102 genome variants, with clinical data in the National Clinical Cohort Collaborative (N3C) repository to accelerate integrative research on detection, diagnosis, and treatment of COVID\u201019\u2010related morbidities. The N3C curated a rich collection of aggregated and de\u2010identified electronic health records (EHR) data of over 18 million patients, including 7.5 million COVID\u2010positive patients, seen at hospitals across the United States. Medical imaging data and variant samples are important data modalities used in the study of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Imaging data and features are hosted on the Cancer Imaging Archive (TCIA), and sequenced variant samples are analyzed and stored at the NIH GenBank. The University of Arkansas for Medical Sciences (UAMS) published the first COVID\u201019 data set of 105 patients on TCIA and 37 patients on GenBank. We developed a process to link imaging and genomic variants and N3C EHR data through Privacy Preserving Record Linkage (PPRL) using de\u2010identified cryptographic hashes to match records associated with the same individuals without using patient identifiers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PPRL techniques were piloted using clinical and imaging data sets provided by UAMS. Developed software components and processes executed properly, and linked data were returned and processed for visualization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Linking across clinical data sources at the patient level provides opportunities to gain insights from data that may not be known otherwise. The PPRL prototype and the pilot serve as a model to link disparate and diverse data repositories to enhance clinical research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lrh2.10457","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:40:11Z","timestamp":1726206011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linking <i>The Cancer Imaging Archive<\/i> and <scp>GenBank<\/scp> to the <scp>National Clinical Cohort Collaborative<\/scp>"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-0021","authenticated-orcid":false,"given":"Ahmad","family":"Baghal","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Saltz","sequence":"additional","affiliation":[{"name":"Stony Brook University The State University of New York, Biomedical Informatics  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahsin","family":"Kurc","sequence":"additional","affiliation":[{"name":"Stony Brook University The State University of New York, Biomedical Informatics  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prateek","family":"Prasanna","sequence":"additional","affiliation":[{"name":"Stony Brook University The State University of New York, Biomedical Informatics  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Baghal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Hajagos","sequence":"additional","affiliation":[{"name":"Stony Brook University The State University of New York, Biomedical Informatics  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Bremer","sequence":"additional","affiliation":[{"name":"Stony Brook University The State University of New York, Biomedical Informatics  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaymaa","family":"Al\u2010Shukri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Internal Medicine University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children's Research Institute  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-7586","authenticated-orcid":false,"given":"Tracy","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Chute","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Prior","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa196"},{"key":"e_1_2_9_3_1","first-page":"1581","article-title":"Secondary use of Patients' electronic records (SUPER): an approach for meeting specific data needs of clinical and translational researchers","volume":"2017","author":"Sholle ET","year":"2017","journal-title":"Ann Symp Proc. 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