{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:53:13Z","timestamp":1788551593971,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH120588"],"award-info":[{"award-number":["R01MH120588"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Learning Health Systems"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Compared to usual care, specialty services for first\u2010episode psychosis (FES) have superior patient outcomes. The Early Psychosis Intervention Network (EPINET), comprised of eight U.S. regional clinical networks, aims to advance the quality of FES care within the ethos of learning healthcare systems (LHS). Among these, the Academic Community (AC) EPINET was established to provide FES care, collect common data elements, leverage informatics, foster a culture of continuous learning and quality improvement, and engage in practice\u2010based research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed and implemented a novel LHS of university\u2010affiliated FES programs within a hub (academic leadership team) and spoke (FES clinics) model. A series of site implementation meetings engaged stakeholders, setting the stage for a culture that values data collection and shared learning. We built clinical workflows to collect common data elements at enrollment and at consecutive 6\u2010month intervals in parallel to an informatics workflow to deliver outcome visualizations and drive quality improvement efforts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All six clinical sites successfully implemented data capture workflows and engaged in the process of designing the informatics platform. Upon developing the structure, processes, and initial culture of the LHS, a total of 614 patients enrolled in AC\u2010EPINET, with the most common primary diagnoses of schizophrenia (32.1%) and unspecified psychotic disorders (23.6%). Visualized outcomes were delivered to clinical teams who began to consider locally relevant quality improvement projects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AC\u2010EPINET is a novel LHS, with a simultaneous focus on science, informatics, incentives, and culture. The work of developing AC\u2010EPINET thus far has highlighted the need for future LHS\u2019 to be mindful of the complexities of data security issues, develop more automated informatic workflows, resource quality assurance efforts, and attend to building the cultural infrastructure with the input of all stakeholders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lrh2.10471","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T07:44:59Z","timestamp":1731915899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states"],"prefix":"10.1002","volume":"9","author":[{"given":"Jenifer L.","family":"Vohs","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Prevention and Recovery Center for Early Psychosis (PARC), Sandra Eskenazi Mental Health Centers Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-2332","authenticated-orcid":false,"given":"Vinod","family":"Srihari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Specialized Treatment Early in Psychosis (STEP) Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra H.","family":"Vinson","sequence":"additional","affiliation":[{"name":"Learning Health Sciences University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Lapidos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Program for Risk Evaluation and Prevention (PREP) Early Psychosis University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Specialized Treatment Early in Psychosis (STEP) Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan F.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Program for Risk Evaluation and Prevention (PREP) Early Psychosis University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Heckers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Vanderbilt Early Psychosis Program Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Early Psychosis Intervention Clinic\u2010New Orleans (EPIC\u2010NOLA) Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Early Psychosis Intervention Clinic\u2010New Orleans (EPIC\u2010NOLA) Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Strong Ties Young Adult Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy F.","family":"Tso","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health, Early Psychosis Intervention Center (EPICENTER) The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J. 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