{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:20:20Z","timestamp":1772896820717,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Photosan<jats:sup>\u00ae<\/jats:sup>, a mixture of porphyrin oligomers as sensitizer for photodynamic therapy (PDT), carry the risk of prolonged photosensitivity of the skin. New sensitizer such as 5\u2010aminolaevulinic acid (ALA) with low rates of skin phototoxicity appear to be promising alternatives. The aim of this study was to evaluate the efficacy of ALA compared to Photosan for PDT in malignant tracheo\u2010bronchial stenosis. Reduction of tumor stenosis, increase in quality of life, and phototoxicity were considered as primary objectives. Improvement in clinical symptoms due to reduction of tumor stenosis, for example hemotysis, dyspnea, and poststenotic pneumonia were considered as secondary objectives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>After diagnostic work\u2010up, photosensitization was done in 16 patients with ALA (60 mg\/kg BW, oral, 6\u20138 hours prior to PDT) and in 24 patients with Phtosan (2 mg\/kg BW, i.v., 48 hours before PDT). The light dose was calculated as 100 J\/cm<jats:sup>2<\/jats:sup> tumor length. Light at 630 nm was applied using a pumped dye laser. In both groups, additional hyperbaric oxygenation was applied at a level of 2 absolute atmospheric pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stenosis diameter and Karnofsky performance status showed a significant improvement in favor of the Photosan\u2010group, <jats:italic>P<\/jats:italic>\u2009=\u20090.00073 and 0.00015, respectively. In both groups no sunburn occurred due to phototoxicity of the sensitizer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the limitations of a non\u2010randomized study, photosensitization with Photosan seems to be more effective in PDT of malignant tracheo\u2010bronchial stenosis compared to ALA. Lasers Surg. Med. 30:12\u201317, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.10009","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"12-17","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of 5\u2010aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: A clinical pilot study"],"prefix":"10.1002","volume":"30","author":[{"given":"Alfred","family":"Maier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Tomaselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Matzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Woltsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Anegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rehak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pinter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Smolle\u2010J\u00fcttner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb04850.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00295-4"},{"key":"e_1_2_1_4_2","first-page":"759","article-title":"Photoradiation therapy in the treatment of advanced carcinoma of the trachea and bronchus","volume":"170","author":"Vincent R","year":"1984","journal-title":"Proc Clin Biol Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02594076"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02547850"},{"key":"e_1_2_1_7_2","first-page":"543","article-title":"Endoscopic management of lung cancer with hematoporphyrin phototherapy","volume":"57","author":"Cortese DA","year":"1982","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900100514"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.284"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.175"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004189"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70297-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(99)00129-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9101(2000)27:4<350::AID-LSM8>3.0.CO;2-R"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(2000)26:3<308::AID-LSM9>3.0.CO;2-B"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00635-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72041-3_4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1001290"},{"key":"e_1_2_1_19_2","first-page":"117","article-title":"Photodynamic therapy of malignant tumours","volume":"2","author":"Diamond I","year":"1972","journal-title":"Lancet"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.288"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70276-8"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1300"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770132"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.1.67"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.10009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.10009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T14:56:20Z","timestamp":1700319380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.10009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/lsm.10009"],"URL":"https:\/\/doi.org\/10.1002\/lsm.10009","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}