{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:49:01Z","timestamp":1792842541339,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,9,25]],"date-time":"2002-09-25T00:00:00Z","timestamp":1032912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To determine the safety and efficacy of 5\u2010aminolevulinic acid (ALA) as a topically applied photosensitizer for photodynamic therapy (PDT) of cervical intraepithelial neoplasia (CIN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Designs\/Materials and Methods<\/jats:title><jats:p>Forty women, who were at least 18 years old with persistent biopsy\u2010proven CIN 2 and CIN 3 within the previous 3 months of enrollment, underwent PDT in a phase I and II design. Five escalating radiant energies (increments of 25 J\/cm<jats:sup>2<\/jats:sup>, beginning at 50\u2013150 J\/cm<jats:sup>2<\/jats:sup>) using a Coherent Dye Model 920 argon pumped dye laser providing light at 630 nm (maximum output 0.8 W) were used to perform PDT with a fixed dose of ALA (200 mg\/ml). ALA was placed in a cervical cap fitted to the cervix. After 90 minutes, the cap was removed and the ectocervix was illuminated for 5\u201316 minutes, depending on the irradiance. Success was defined as the absence of CIN on Pap smear or colposcopic examination at 12\u2010months. Patients were monitored for toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two women (80%) completed the study with 1 year of follow\u2010up. Sixty percent had CIN 3 and 40% CIN 2. Success rates at 4, 8, and 12 months were 51, 46, and 31%, respectively, and were not light\u2010dose dependent. Three patients progressed from CIN 2 to CIN 3. Toxicity was tolerable and only consisted of spotting, vaginal discharge, mild cramping, and vaginal warmth. There was no apparent dose relationship to toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDT at this light and ALA dose is well tolerated but has minimal activity in the treatment of CIN 2 and CIN 3. Other doses and schedules of light and ALA or novel photosensitizers may improve efficacy. Lasers Surg. Med. 31:289\u2013293, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.10111","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:57:12Z","timestamp":1034139432000},"page":"289-293","source":"Crossref","is-referenced-by-count":59,"title":["Photodynamic therapy of high\u2010grade cervical intraepithelial neoplasia with 5\u2010aminolevulinic acid"],"prefix":"10.1002","volume":"31","author":[{"given":"Kristin 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