{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:05:39Z","timestamp":1790885139868,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,3]],"date-time":"2003-01-03T00:00:00Z","timestamp":1041552000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      Experimental assessment of photodynamic therapy (PDT) for malignant pleural mesothelioma using a polyethylene glycol conjugate of\n                      <jats:italic>meta<\/jats:italic>\n                      \u2010tetrahydroxyphenylchlorin (PEG\u2013\n                      <jats:italic>m<\/jats:italic>\n                      THPC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design\/Materials and Methods<\/jats:title>\n                    <jats:p>\n                      (a) PDT was tested on H\u2010meso\u20101 xenografts (652 nm laser light; fluence 10 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ; 0.93, 9.3, or 27.8 mg\/kg of PEG\u2013\n                      <jats:italic>m<\/jats:italic>\n                      THPC; drug\u2010light intervals 3\u20138 days). (b) Intraoperative PDT with similar treatment conditions was performed in the chest cavity of minipigs (n\u2009=\u200918) following extrapleural pneumonectomy (EPP) using an optical integrating balloon device combined with in situ light dosimetry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      (a) PDT using PEG\u2013\n                      <jats:italic>m<\/jats:italic>\n                      THPC resulted in larger extent of tumor necrosis than in untreated tumors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.01) without causing damage to normal tissue. (b) Intraoperative PDT following EPP was well tolerated in 17 of 18 animals. Mean fluence and fluence rates measured at four sites of the chest cavity ranged from 10.2\u2009\u00b1\u20090.2 to 13.2\u2009\u00b1\u20092.3 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      and 5.5\u2009\u00b1\u20091.2 to 7.9\u2009\u00b1\u20091.7 mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      (mean\u2009\u00b1\u2009SD). Histology 3 months after light delivery revealed no PDT related tissue injury in all but one animal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PEG\u2013\n                      <jats:italic>m<\/jats:italic>\n                      THPC mediated PDT showed selective destruction of mesothelioma xenografts without causing damage to intrathoracic organs in pigs at similar treatment conditions. The light delivery system afforded regular light distribution to different parts of the chest cavity. Lasers Surg. Med. 32:61\u201368,2003. \u00a9 2003 Wiley\u2010Liss, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.10113","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T16:16:28Z","timestamp":1041956188000},"page":"61-68","source":"Crossref","is-referenced-by-count":24,"title":["Experimental photodynamic therapy for malignant pleural mesothelioma with pegylated\n                    <i>m<\/i>\n                    THPC"],"prefix":"10.1002","volume":"32","author":[{"given":"Thorsten","family":"Krueger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Altermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Beat","family":"Ris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1,3]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"113","article-title":"Malignant pleural mesothelioma. 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