{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:58:37Z","timestamp":1772913517838,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Nd:YAG laser\u2010induced thermo therapy (LITT) of rat brains is associated with blood\u2013brain barrier (BBB) permeability changes. We address the question of whether LITT\u2010induced locoregional disruption of the BBB could possibly allow a locoregional passage of chemotherapeutic agents into brain tissue to treat malignant glioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>CD Fischer rats were subject to LITT of the left forebrain. Disruption of the BBB was analyzed using Evans blue and immunohistochemistry (IH). Animals were perfused with paclitaxel, and high\u2010pressure liquid chromatography (HPLC) was employed to analyze the content of paclitaxel in brain and plasma samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LITT induces an opening of the BBB as demonstrated by locoregional extravasation of Evans blue, C3C, fibrinogen, and IgM. HPLC proved the passage of paclitaxel across the disrupted BBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LITT induces a locoregional passage of chemotherapeutic agents into the brain tissue. This is of potential interest for the treatment of brain tumors. Lasers Surg. Med. 33:75\u201380, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.10181","type":"journal-article","created":{"date-parts":[[2003,8,7]],"date-time":"2003-08-07T15:43:02Z","timestamp":1060270982000},"page":"75-80","source":"Crossref","is-referenced-by-count":40,"title":["Locoregional opening of the rodent blood\u2013brain barrier for paclitaxel using Nd:YAG laser\u2010induced thermo therapy: A new concept of adjuvant glioma therapy?"],"prefix":"10.1002","volume":"33","author":[{"given":"Michael","family":"Sabel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kondakci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Gorol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Willers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bilzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199805000-00082"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198007000-00007"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90536-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140310"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1983.tb00120.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01412303"},{"key":"e_1_2_1_8_2","first-page":"36","article-title":"Technische Voraussetzungen f\u00fcr die interstitielle thermotherapie mit dem Nd.YAG Laser","volume":"0","author":"Frank F","year":"1990","journal-title":"Lasermedizin"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001170050133"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070135"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.200.1.8657903"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198504000-00001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.6.0909"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900130212"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.60.3.0531"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.14.1077"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/clm.1992.10.37","article-title":"Interstitial laserthermia in neurosurgery","volume":"10","author":"Sakai T","year":"1992","journal-title":"J Clin Laser Med Surg"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/02656739409009357"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62044-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454898"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb01858.x"},{"key":"e_1_2_1_22_2","first-page":"622","article-title":"Blood\u2013brain barrier breakdown by cold injury. 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