{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:03:38Z","timestamp":1765231418935},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,5,2]],"date-time":"2001-05-02T00:00:00Z","timestamp":988761600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Intimal hyperplasia (IH) leading to restenosis is a major complication of arterial revascularization. The purpose of this study was to investigate the effect of photodynamic therapy (PDT) using mono\u2010L\u2010aspartyl chlorin e6 (NPe6) as a photosensitizer and intraluminal radial irradiation for inhibition of IH experimentally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Study of laser transmission through the blood indicated that exclusion of blood is a prerequisite for intraluminal PDT. For homogeneous radial laser irradiation to the vessel wall, we used a newly developed cylindrical diffusing balloon laser fiber. Injuries were induced by pulling a balloon catheter through the right iliac artery of rabbits. One and 6 hours after the NPe6 injection (5mg\/kg i.v.), drug distribution was examined by fluorescence microscopy. Nineteen rabbits received NPe6 at the time of injuries and PDT was performed with 664\u2010nm laser at 30 and 10 J\/cm<jats:sup>2<\/jats:sup> (20, 30, 40 mW\/cm<jats:sup>2<\/jats:sup>) 1 hour after the injuries. The arteries were harvested at 2 days. In a second group of rabbits, PDT was given at 30 mW\/cm<jats:sup>2<\/jats:sup> (30 J\/cm<jats:sup>2<\/jats:sup>). Two weeks after treatment, the arteries were removed and examined histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NPe6 was found to be distributed selectively in the injured media. Endovascular NPe6\u2010PDT showed complete depletion of smooth muscle cells even with 10 J\/cm<jats:sup>2<\/jats:sup> at 2 days. IH was significantly inhibited at 14 days after PDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endovascular PDT of injured artery using NPe6 can prevent IH in this model of arterial wall injury and may become clinically useful for the prophylaxis of IH. Lasers Surg. Med. 28:381\u2013388, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.1066","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:24:15Z","timestamp":1030307055000},"page":"381-388","source":"Crossref","is-referenced-by-count":24,"title":["Endovascular photodynamic therapy using mono\u2010L\u2010aspartyl\u2010chlorin e6 to inhibit Intimal hyperplasia in balloon\u2010injured rabbit 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