{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:31:38Z","timestamp":1791498698818,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,9,20]],"date-time":"2001-09-20T00:00:00Z","timestamp":1000944000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>REM syndrome (reticular erythematous mucinosis) is a benign but bothersome skin disease that common occurs in middle age and among women. Local and systemic treatment measures are often associated with a high rate of side effects and relapses are common. We evaluated the pulsed dye laser as an alternative method because of its good efficacy in vascular skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>We treated two female patients with REM syndrome using the pulsed dye laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both patients the erythematous skin changes were almost completely removed after five and three laser sessions, respectively. Other than transient hypopigmentation, no side effects occurred. In one case there is still no evidence of recurrence 6 years after a trial treatment was conducted. In the same patient, clinical success was histologically confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report on the successful treatment of REM syndrome of two female patients with the pulsed dye laser. Lasers Surg. Med. 29:248\u2013251, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.1115","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:24:42Z","timestamp":1030310682000},"page":"248-251","source":"Crossref","is-referenced-by-count":23,"title":["Treating REM syndrome with the pulsed dye laser"],"prefix":"10.1002","volume":"29","author":[{"given":"Baerbel","family":"Greve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Raulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,9,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb15865.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1990.tb01065.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1987.tb01853.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1986.tb02929.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/archderm.1979.04010110046025","article-title":"Reticular erythematous mucinosis syndrome","volume":"115","author":"Morison WL","year":"1979","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70246-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb03521.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00896.x"},{"key":"e_1_2_1_10_2","first-page":"986","article-title":"Retikul\u00e4re erythemat\u00f6se Muzinose (REM)","volume":"63","author":"Ingber A","year":"1988","journal-title":"Z Hautkr"},{"key":"e_1_2_1_11_2","first-page":"25","article-title":"Plaque\u2010artige Form der cutanen Mucinose (PCM) und retikul\u00e4re erythemat\u00f6se Mucinosis (REM\u2010Syndrom)","volume":"50","author":"Steigleder GK","year":"1975","journal-title":"Z Hautkr"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2340\/0001555557465467","article-title":"Reticular erythematous mucinosis syndrome: report of a case","volume":"57","author":"Dal BL","year":"1977","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70257-G"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90346-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1001\/archderm.1991.01680020070007","article-title":"Capillary hemangiomas and treatment with the flash lamp\u2010pumped pulsed dye laser","volume":"127","author":"Ashinoff R","year":"1991","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050051155"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03203.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70094-A"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050988"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.129.3.381"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199402000-00015"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90501-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91989-9"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T02:07:52Z","timestamp":1696644472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/lsm.1115"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1115","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}