{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:37:25Z","timestamp":1791074245643,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,11]],"date-time":"2001-10-11T00:00:00Z","timestamp":1002758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>One of the approaches to enhance the selectivity and efficiency of photodynamic therapy (PDT) was the conjugation of the photosensitizer meta\u2010tetrahydroxyphenylchlorin (mTHPC) to the water\u2010soluble polymer polyethylene glycol (PEG). Several studies have demonstrated that mTHPC\u2010PEG has a higher selectivity and a longer circulating half\u2010life than free mTHPC, whereas no in vivo effect of this benefit could be seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>In a model of RAG\u20102\u2010mice bearing a human oral squamous cell carcinoma xenograft (XF 354), the in vivo efficiency assessed as growth retardation or remission caused by Photofrin II and free mTHPC was compared with mTHPC coupled in two different ways to polyethylene glycol (PEG). One hundred and fourty\u2010nine female RAG\u20102\u2010mice were randomised into one control group and 13 therapy groups. Treatment parameters were adapted from those routinely applied in animal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Photofrin II\u2010mediated PDT and mTHPC\u2010mediated PDT were both in vivo highly effective, whereas mTHPC induced less scars. The in vivo results after mTHPC\u2010PEG\u2010mediated PDT were disappointing, whereas the effectiveness of mTHPCnPEG\u2010mediated PDT, a newly coupled macromolecular photosensitizer, were promising.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrated the impact of the method of linkage between the photoactive agent mTHPC and polyethylene glycol (PEG) upon the in vivo effectiveness. mTHPC and mTHPCnPEG are promising photosensitizers for the future, especially for the cosmetic treatment needs of head and neck surgery. Lasers Surg. Med. 29:314\u2013322, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.1123","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T14:13:25Z","timestamp":1098972805000},"page":"314-322","source":"Crossref","is-referenced-by-count":32,"title":["Comparison of the in vivo efficiency of photofrin II\u2010, mTHPC\u2010, mTHPC\u2010PEG\u2010 and mTHPCnPEG\u2010mediated PDT in a human xenografted head and neck carcinoma"],"prefix":"10.1002","volume":"29","author":[{"given":"Tobias","family":"Reuther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"K\u00fcbler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Zillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Flechtenmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannsj\u00f6rg","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Die photodynamische Therapie in der Mund\u2010, Kiefer\u2010, Gesichtschirurgie. Untersuchungen zur klinischen Einf\u00fchrung eines neuen, organerhaltenden Tumortherapieverfahrens","author":"K\u00fcbler AC","year":"1999"},{"key":"e_1_2_1_3_2","first-page":"115","article-title":"Chemical mechanisms of photodynamic action Proc. SPIE Institute Advanced Optical Technologies on Photodynamic Therapy","volume":"6","author":"Foote CS","year":"1990","journal-title":"IS"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2610277"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1991.tb02133.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570618"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600320"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550213"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1998)23:1<25::AID-LSM4>3.0.CO;2-Y"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910590620"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980610)76:6<842::AID-IJC13>3.0.CO;2-4"},{"key":"e_1_2_1_12_2","first-page":"45","article-title":"Comparison of the influence of a water\u2010soluble polymer carrier on the tumor localization and biodistribution of the mesotetrametahydroxyphenylchlorin (mTHPC) in two animal models","volume":"2371","author":"Westermann P","year":"1995","journal-title":"SPIE"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301213280306"},{"key":"e_1_2_1_14_2","volume-title":"Experimentelle und klinische Untersuchungen zur Wirkung ionisierender Strahlen auf die Gewebe im Bereich der Mundh\u00f6hle M\u00fcnchen, Wien","author":"Wannenmacher M","year":"1976"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199309000-00005"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb07383.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(80)90025-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(84)90025-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4406-3_13"},{"key":"e_1_2_1_20_2","first-page":"13","volume-title":"Methods in Porphyrin Photosensitization","author":"Cai WM","year":"1985"},{"key":"e_1_2_1_21_2","first-page":"27","article-title":"Photodynamic therapy in the treatment of malignancies","volume":"26","author":"Gomer CL","year":"1989","journal-title":"Semin Hematol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00191-7"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1017\/S0022215100132050","article-title":"Treatment of head and neck cancer with photodynamic therapy: results after one year","volume":"109","author":"Dilkes MG","year":"1995","journal-title":"J Laryngol Otol"},{"key":"e_1_2_1_24_2","first-page":"23","article-title":"m\u2010THPC photodynamic therapy for head and neck cancer Lasers","volume":"11","author":"Dilkes MG","year":"1996","journal-title":"Med Sci"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970926)73:1<25::AID-IJC5>3.0.CO;2-3"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910630209"},{"key":"e_1_2_1_27_2","unstructured":"SinnH. Controlled use of polyether\u2010substituted tumor agents in diagnosis and therapy. Patent No. WO93\/10743 1991."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb01714.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.86"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:48:57Z","timestamp":1700416137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,11]]},"references-count":28,"aliases":["10.1002\/lsm.1123.abs"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1002\/lsm.1123"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1123","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,11]]}}}